commipholactam A，一种来自 Commiphora 树脂的细胞毒性倍半萜类内酯。

Commipholactam A, a cytotoxic sesquiterpenoidal lactam from Resina Commiphora.

机构信息

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650500, PR China.

Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, PR China.

出版信息

Fitoterapia. 2019 Apr;134:382-388. doi: 10.1016/j.fitote.2019.03.008. Epub 2019 Mar 16.

DOI:10.1016/j.fitote.2019.03.008

PMID:30890423

Abstract

Diverse terpenoids including a novel sesquiterpenoidal lactam, commipholactam A (1), and a structurally related new cadinane sesquiterpenoid, commiphorane H (2), a new eudesmane sesquiterpenoid, commiphorane I (4), a new guaiane sesquiterpenoid, commiphorane J (5), and two new nor-abietane diterpenoids, commiphoranes K1 and K2 (6 and 7) along with two known terpenoids (3 and 8), were isolated from Resina Commiphora. Their structures with absolute configurations were characterized by spectroscopic methods and calculated electronic circular dichroism (ECD). Notably, commipholactam A represents the first example of cadinane sesquiterpene alkaloids isolated from Resina Commiphora. Biological assessment toward human cancer cells showed that the IC values of 1 against HepG2 and A549 cells were 21.73 μM and 128.50 μM, respectively.

摘要

从乳香树脂中分离得到了多种萜类化合物，包括一种新型的倍半萜内酰胺，即commipholactam A（1），以及一种结构相关的新型卡达烷倍半萜，commiphorane H（2），一种新的愈创木烷倍半萜，commiphorane I（4），一种新的半日花烷倍半萜，commiphorane J（5），以及两种新的愈创木烷二萜，commiphoranes K1 和 K2（6 和 7），以及两种已知的萜类化合物（3 和 8）。它们的结构和绝对构型通过光谱方法和计算电子圆二色性（ECD）进行了表征。值得注意的是，commipholactam A 是从乳香树脂中分离得到的第一个卡达烷倍半萜生物碱的例子。对人癌细胞的生物评估表明，化合物 1 对 HepG2 和 A549 细胞的 IC 值分别为 21.73 μM 和 128.50 μM。