Lyon 1 University, UMR CNRS 5223, IMP, 15 boulevard André Latarjet, 69622 Villeurbanne, Cedex, France.
Lyon 1 University, UMR CNRS 5223, IMP, 15 boulevard André Latarjet, 69622 Villeurbanne, Cedex, France.
J Control Release. 2020 Oct 10;326:150-163. doi: 10.1016/j.jconrel.2020.06.012. Epub 2020 Jun 18.
Sustainable and controlled delivery of drugs is at the centre of a huge amount of undertaken researches. The ability of hydrogels, high water content materials, to achieve a local and delayed-delivery has already been demonstrated for a wide variety of therapeutic agents and various polymer natures. In particular, chitosan, a natural polymer, stands out as a first choice material for hydrogels elaboration in biomedical, cosmetic, and health related applications, owing to its interesting properties (as biocompatibility, biodegradability, antimicrobial capacity, and mucoadhesivity). Moreover, chitosan also allows drugs to go easier through biological barriers. The main objective of this review is to report the various uses of chitosan hydrogels as drug delivery devices to control and/or delay the release of drugs loaded into their three dimensional matrix. A wide spectrum of corresponding biomedical applications of these systems can be encountered in the literature, whatever the physicochemical nature of drugs (hydrophilic, hydrophobic, macromolecular), as detailed in this review.
药物的可持续和控制释放是大量研究的核心。水凝胶是一种高含水量的材料，具有实现局部和延迟释放的能力，已经在各种治疗剂和各种聚合物性质中得到了证明。特别是壳聚糖作为天然聚合物，由于其具有生物相容性、可生物降解性、抗菌能力和粘膜粘附性等有趣的特性，在生物医学、化妆品和健康相关应用的水凝胶制备中脱颖而出。此外，壳聚糖还可以使药物更容易通过生物屏障。本文的主要目的是报告壳聚糖水凝胶作为药物传递装置的各种用途，以控制和/或延迟负载于其三维基质中的药物的释放。无论药物的物理化学性质如何（亲水性、疏水性、大分子），都可以在文献中遇到这些系统的广泛的相应的生物医学应用，如本综述所述。
