Kamiza Abram Bunya, Kamiza Steve, Mathew Christopher George
Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Histopathology Department, College of Medicine, University of Malawi, Blantyre, Malawi.
Cancer Epidemiol. 2020 Aug;67:101748. doi: 10.1016/j.canep.2020.101748. Epub 2020 Jun 17.
Human leukocyte antigens (HLA) are encoded by closely linked genetic loci, and are important in cervical carcinogenesis. The association between HLA-DRB1 alleles with cervical cancer has been studied extensively, but results reported thus far have been inconsistent. Hence, we performed a meta-analysis to precisely assess this association.
A literature search was conducted in various online databases to identify suitable articles. Case-control studies investigating the association between HLA-DRB1 alleles and cervical cancer were included in this study. Fixed and random-effect models were used to calculate the pooled odds ratio (OR) and 95% confidence intervals (CIs).
A total of 6645 cases and 9095 controls from 36 case-control studies were included. Of the 13 HLA-DRB1 family alleles, DRB109 (OR = 1.30) and DRB1 15 (OR = 1.60) were associated with cervical cancer risk, whilst DRB113 (OR = 0.66) exerted a protective effect. Among the 44 HLA-DRB1 specific alleles, DRB104:01 (OR = 1.25), DRB110:01 (OR = 1.45), DRB111:01 (OR = 1.32), DRB115:01 (OR = 1.21) and DRB115:02 (OR = 1.55) were associated with an increased risk of cervical cancer. However, DRB104:06 (OR = 0.52), DRB112:02 (OR = 0.61), DRB113:01 (OR = 0.62), DRB113:02 (OR = 0.57), and DRB1*14:04 (OR = 0.37) were associated with a decreased risk of cervical cancer. Subgroup analysis also revealed that HLA-DRB1 alleles are associated with cervical cancer in Asian, Caucasian, Hispanic or Latin American and black sub-Saharan Africa populations.
Our meta-analysis revealed that multiple HLA-DRB1 alleles are associated with cervical cancer in women of diverse ancestry populations.
人类白细胞抗原（HLA）由紧密连锁的基因座编码，在宫颈癌发生过程中起重要作用。HLA - DRB1等位基因与宫颈癌之间的关联已得到广泛研究，但迄今为止报道的结果并不一致。因此，我们进行了一项荟萃分析以精确评估这种关联。
在多个在线数据库中进行文献检索以识别合适的文章。本研究纳入了调查HLA - DRB1等位基因与宫颈癌之间关联的病例对照研究。采用固定效应模型和随机效应模型计算合并比值比（OR）和95%置信区间（CI）。
共纳入36项病例对照研究中的6645例病例和9095例对照。在13个HLA - DRB1家族等位基因中，DRB109（OR = 1.30）和DRB115（OR = 1.60）与宫颈癌风险相关，而DRB113（OR = 0.66）具有保护作用。在44个HLA - DRB1特异性等位基因中，DRB104:01（OR = 1.25）、DRB110:01（OR = 1.45）、DRB111:01（OR = 1.32）、DRB115:01（OR = 1.21）和DRB115:02（OR = 1.55）与宫颈癌风险增加相关。然而，DRB104:06（OR = 0.52）、DRB112:02（OR = 0.61）、DRB113:01（OR = 0.62）、DRB113:02（OR = 0.57）和DRB1*14:04（OR = 0.37）与宫颈癌风险降低相关。亚组分析还显示，HLA - DRB1等位基因在亚洲、白种人、西班牙裔或拉丁美洲以及撒哈拉以南非洲黑人人群中与宫颈癌相关。
我们的荟萃分析表明，多个HLA - DRB1等位基因与不同种族人群女性的宫颈癌相关。
