Georgopoulos Apostolos P, James Lisa M
The HLA Research Group, Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, MN, 55417, USA.
Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
J Immunol Sci. 2022 May 5;6(2):6-17. doi: 10.29245/2578-3009/2022/2.1227.
Human leukocyte antigen (HLA) genes have been associated with susceptibility and protection against a number of cancers. Here we used an immunogenetic epidemiological approach to evaluate the overall influence of 127 HLA Class I and II alleles on 30 types of cancer. We found a preponderance of protective alleles (negatively correlated with cancer prevalences), especially for HLA Class I. Of the 30 cancers investigated, 13 were associated with mostly protective HLA effects whereas only 2 were associated with mostly susceptibility HLA alleles. Taken together, these findings highlight the broad influence of HLA on cancer and the complexity of HLA-cancer associations.
人类白细胞抗原（HLA）基因与多种癌症的易感性和保护性相关。在此，我们采用免疫遗传学流行病学方法，评估127种HLA I类和II类等位基因对30种癌症类型的总体影响。我们发现保护性等位基因占优势（与癌症患病率呈负相关），尤其是HLA I类。在研究的30种癌症中，13种主要与HLA的保护作用相关，而只有2种主要与HLA易感等位基因相关。综上所述，这些发现凸显了HLA对癌症的广泛影响以及HLA与癌症关联的复杂性。
