Departament of Obstetrics and Gynecology, Hospital La Zarzuela, Madrid, Spain; Universidad Francisco de Vitoria, Faculty of Medicine, Pozuelo de Alarcon, Madrid, Spain.
Departament of Obstetrics and Gynecology, Hospital La Zarzuela, Madrid, Spain.
Eur J Obstet Gynecol Reprod Biol. 2020 Sep;252:43-49. doi: 10.1016/j.ejogrb.2020.06.019. Epub 2020 Jun 9.
The aim of the study is to assess whether women who choose to use menopausal hormone therapy (MHT) have lower quality of life (QoL) than those who do not initiate it using Cervantes short form scale (C-SF), and analyze sociodemographic factors associated with lower QoL in women.
A cross-sectional descriptive observational study was made in four hundred and eighty women with climacteric symptoms.
Mean age was 51.1 years. Two hundred and sixty-one women (54.3 %) started MHT. The sample´s global mean in C-SF score was 51.3 ± 13.9. Women who choose to use MHT have higher score in C-SF (lower QoL) than women who reject it (58.7 ± 15.9 vs 46.7 ± 12.8; p < 0.001). We found higher score in women with early menopause (53.7 ± 15.9 vs 49.7 ± 13.1; p = 0.037); with no obesity (<30 vs >30 BMI) (52.8 ± 13.5 vs 41.0 ± 8.2; p = 0.002); with previous malignancies (56.2 ± 18.2 vs 50.2 ± 13.5; p = 0.020) and without sexual activity (58.0 ± 25.4 vs 50.4 ± 13.1; p = 0.009. No differences were found in C-SF score with respect to tobacco habits or physical activity. In the multivariate analysis, the variable independently associated to lower QoL by C-SF (high score) was to be a woman who want to initiate MHT (p = 0.004).
Women who choose to use MHT due to menopausal symptoms have lower quality of life measured by C-SF scale. Women with early menopause, with no obesity (<30 BMI), without sexual activity and with previous malignances have lower quality of life measured by C-SF scale. Women with early menopause have more psychic symptoms like nervousness, fatigue and sleep complaints by C-SF scale than women with natural menopause.
本研究旨在评估选择使用更年期激素治疗（MHT）的女性与未使用 Cervantes 短式量表（C-SF）启动 MHT 的女性相比，生活质量（QoL）是否更低，并分析与女性 QoL 降低相关的社会人口学因素。
对 480 名有更年期症状的女性进行了横断面描述性观察研究。
平均年龄为 51.1 岁。261 名女性（54.3%）开始使用 MHT。C-SF 评分的样本全球平均值为 51.3±13.9。选择使用 MHT 的女性 C-SF 评分较高（生活质量较低），而拒绝使用 MHT 的女性 C-SF 评分较低（58.7±15.9 vs 46.7±12.8；p<0.001）。我们发现，绝经较早的女性评分较高（53.7±15.9 vs 49.7±13.1；p=0.037）；无肥胖症（<30 BMI 与 >30 BMI）的女性评分较高（52.8±13.5 vs 41.0±8.2；p=0.002）；有既往恶性肿瘤的女性评分较高（56.2±18.2 vs 50.2±13.5；p=0.020）；无性生活的女性评分较高（58.0±25.4 vs 50.4±13.1；p=0.009）。C-SF 评分与吸烟习惯或体力活动无关。多变量分析表明，与 C-SF（高评分）相关的独立生活质量较低的变量是女性希望启动 MHT（p=0.004）。
由于更年期症状而选择使用 MHT 的女性生活质量（通过 C-SF 量表衡量）较低。绝经较早、无肥胖症（<30 BMI）、无性生活和有既往恶性肿瘤的女性生活质量（通过 C-SF 量表衡量）较低。与自然绝经的女性相比，有早期绝经的女性通过 C-SF 量表有更多的精神症状，如紧张、疲劳和睡眠问题。
