Kiloh L G, Andrews G, Neilson M
University of New South Wales, Australia.
Br J Psychiatry. 1988 Dec;153:752-7. doi: 10.1192/bjp.153.6.752.
One hundred and forty-five patients with primary depressive illness admitted to a university hospital between 1966 and 1970 were followed up an average of 15 years later. Adequate data were obtained on 133 (92%) of the 145. During the follow-up period, 7% of the 133 had suicided, 12% had remained incapacitated by illness and only 20% had remained continuously well. Patients for whom the index admission was not their first were especially likely to be readmitted during the follow-up period. Patients with endogenous depression, none of whom developed schizophrenia during the follow-up period, were more likely to need readmission than patients with an index diagnosis of neurotic depression. In all other respects the prognosis for the two types of depression was the same, with considerable morbidity evident in both.
1966年至1970年间入住一所大学医院的145例原发性抑郁症患者在平均15年后接受了随访。在这145例患者中，有133例（92%）获得了充分的数据。在随访期间，133例患者中有7%自杀，12%仍因疾病而丧失能力，只有20%一直状况良好。首次入院并非其首次住院的患者在随访期间尤其容易再次入院。内源性抑郁症患者在随访期间均未发展为精神分裂症，与首次诊断为神经症性抑郁症的患者相比，他们更有可能需要再次入院。在所有其他方面，这两种抑郁症的预后相同，两种类型的抑郁症都有相当明显的发病率。
