Zhao Zhiqiang, Yang Fujun, Zhang Xuanbo, Sun Jin, He Zhonggui, Luo Cong
Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Biomaterials. 2020 Oct;255:120200. doi: 10.1016/j.biomaterials.2020.120200. Epub 2020 Jun 12.
Thrombus causes insufficient blood flow and ischemia damages to brain and heart, leading to life-threatening cardio-cerebrovascular diseases. Development of efficient antithrombotic strategies has long been a high priority, owing to the high morbidity and mortality of thrombotic diseases. With the rapid development of biomedical nanotechnology in diagnosis and treatment of thrombotic disorder, remarkable progresses have been made in antithrombotic nanomedicines in recent years. Herein, we outline the recent advances in this field at the intersection of thrombus theranostics and biomedical nanotechnology. First, thrombus diagnosis techniques based on biomedical nanotechnology are presented. Then, emerging antithrombotic nanotherapeutics are overviewed, including thrombus-targeting strategies, thrombus stimuli-responsive nanosystems and phase transition-driven nanotherapeutics. Furthermore, multifunctional nanosystems for combination theranostics of thrombotic diseases are discussed. Finally, the design considerations, advantages and challenges of these biomedical nanotechnology-driven therapeutics in clinical translation are highlighted.
血栓会导致血流不足以及对大脑和心脏的缺血性损伤，进而引发危及生命的心脑血管疾病。由于血栓性疾病的高发病率和高死亡率，长期以来，开发有效的抗血栓策略一直是重中之重。随着生物医学纳米技术在血栓性疾病诊断和治疗方面的迅速发展，近年来抗血栓纳米药物取得了显著进展。在此，我们概述了血栓诊疗与生物医学纳米技术交叉领域的最新进展。首先，介绍了基于生物医学纳米技术的血栓诊断技术。然后，综述了新兴的抗血栓纳米疗法，包括血栓靶向策略、血栓刺激响应纳米系统和相变驱动纳米疗法。此外，还讨论了用于血栓性疾病联合诊疗的多功能纳米系统。最后，强调了这些生物医学纳米技术驱动疗法在临床转化中的设计考量、优势和挑战。
