Department of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No.37, Guoxue Alley, Chengdu, 610041, China.
West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.
J Nanobiotechnology. 2023 Jul 7;21(1):212. doi: 10.1186/s12951-023-01977-1.
Although cancer immunotherapy is a compelling approach against cancer, its effectiveness is hindered by the challenge of generating a robust and durable immune response against metastatic cancer cells. Nanovaccines, specifically engineered to transport cancer antigens and immune-stimulating agents to the lymph nodes, hold promise in overcoming these limitations and eliciting a potent and sustained immune response against metastatic cancer cells. This manuscript provides an in-depth exploration of the lymphatic system's background, emphasizing its role in immune surveillance and tumor metastasis. Furthermore, it delves into the design principles of nanovaccines and their unique capability to target lymph node metastasis. The primary objective of this review is to provide a comprehensive overview of the current advancements in nanovaccine design for targeting lymph node metastasis, while also discussing their potential to enhance cancer immunotherapy. By summarizing the state-of-the-art in nanovaccine development, this review aims to shed light on the promising prospects of harnessing nanotechnology to potentiate cancer immunotherapy and ultimately improve patient outcomes.
尽管癌症免疫疗法是一种针对癌症的有效方法，但它的效果受到生成针对转移性癌细胞的强大和持久免疫反应的挑战的阻碍。纳米疫苗专门设计用于将癌症抗原和免疫刺激剂运送到淋巴结，有望克服这些限制，并引发针对转移性癌细胞的有效和持久的免疫反应。本文深入探讨了淋巴系统的背景，强调了它在免疫监视和肿瘤转移中的作用。此外，还探讨了纳米疫苗的设计原则及其靶向淋巴结转移的独特能力。本文的主要目的是全面概述针对淋巴结转移的纳米疫苗设计的最新进展，同时讨论它们在增强癌症免疫疗法方面的潜力。通过总结纳米疫苗开发的最新技术，本文旨在阐明利用纳米技术增强癌症免疫疗法并最终改善患者预后的前景。
