Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, China.
J Control Release. 2024 Jun;370:653-676. doi: 10.1016/j.jconrel.2024.05.014. Epub 2024 May 15.
Pyroptosis, a non-apoptotic programmed cellular inflammatory death mechanism characterized by gasdermin (GSDM) family proteins, has gathered significant attention in the cancer treatment. However, the alarming clinical trial data indicates that pyroptosis-mediated cancer therapeutic efficiency is still unsatisfactory. It is essential to integrate the burgeoning biomedical findings and innovations with potent technology to hasten the development of pyroptosis-based antitumor drugs. Considering the rapid development of pyroptosis-driven cancer nanotherapeutics, here we aim to summarize the recent advances in this field at the intersection of pyroptosis and nanotechnology. First, the foundation of pyroptosis-based nanomedicines (NMs) is outlined to illustrate the reliability and effectiveness for the treatment of tumor. Next, the emerging nanotherapeutics designed to induce pyroptosis are overviewed. Moreover, the cross-talk between pyroptosis and other cell death modalities are discussed, aiming to explore the mechanistic level relationships to provide guidance strategies for the combination of different types of antitumor drugs. Last but not least, the opportunities and challenges of employing pyroptosis-based NMs in potential clinical cancer therapy are highlighted.
细胞焦亡，一种非细胞凋亡的程序性细胞炎症死亡机制，其特征是 Gasdermin（GSDM）家族蛋白，在癌症治疗中受到了广泛关注。然而，令人震惊的临床试验数据表明，细胞焦亡介导的癌症治疗效率仍然不尽人意。将新兴的生物医学发现和创新与强大的技术相结合，以加速基于细胞焦亡的抗肿瘤药物的开发至关重要。鉴于细胞焦亡驱动的癌症纳米治疗的快速发展，我们旨在总结该领域在细胞焦亡与纳米技术交叉点的最新进展。首先，概述了基于细胞焦亡的纳米药物（NMs）的基础，以说明其治疗肿瘤的可靠性和有效性。接下来，综述了旨在诱导细胞焦亡的新兴纳米疗法。此外，讨论了细胞焦亡与其他细胞死亡方式之间的串扰，旨在探索机制水平的关系，为不同类型的抗肿瘤药物联合提供指导策略。最后但同样重要的是，强调了在潜在的临床癌症治疗中使用基于细胞焦亡的 NMs 的机会和挑战。
