Shen Z W, Sun Z J, Yu C Q, Guo Y, Bian Z, Pei P, Du H D, Chen J S, Chen Z M, Lyu J, Li L M
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Jun 10;41(6):813-818. doi: 10.3760/cma.j.cn112338-20191005-00716.
To examine the association between height loss and calcaneus bone mineral density (BMD) through data gathered from the China Kadoorie Biobank (CKB). The present study included 24 231 participants who attended the CKB resurvey during 2013-2014, in which calcaneus BMD was measured by quantitative ultrasound method for the first time. Height loss was calculated according to the differences appeared in height measurement between baseline and resurvey. We used linear regression models to estimate the association between height loss and BMD measures. The mean interval between baseline and resurvey was (8.0±0.8 ) years. 33.0 of the participants showed a height loss of ≥1.0 cm, and another 3.7 were with height loss of ≥3.0 cm. After adjustment for potential confounders, there was a linear correlation seen between height loss and BMD ( for all linear trend were <0.001). The s (95s) for each 1.0 cm of height loss were -0.79 (-0.95--0.63) for broadband ultrasound attenuation (BUA), -2.74 (-3.35--2.13) for speed of sound (SOS), and -1.29 (-1.54--1.04) for stiffness index (SI). Compared with participants with stable height, the multivariate-adjusted s (95s) for those with height loss of ≥3.0 cm were -3.29 (-4.08--2.50) for BUA, -10.70 (-13.66--7.73) for SOS, and -5.16 (-6.36--3.96) for SI, respectively. According to the subgroup analyses, the association of height loss with BMD measures seemed to be more apparent among females, in those aged ≥55 years, and those being less physically active. BMD became lower with the increase of height loss. Regular height measurement may contribute to the early diagnosis and prevention of osteoporosis.
通过中国嘉道理生物样本库（CKB）收集的数据，研究身高降低与跟骨骨密度（BMD）之间的关联。本研究纳入了2013 - 2014年参加CKB再次调查的24231名参与者，其中首次采用定量超声方法测量跟骨骨密度。根据基线和再次调查时身高测量的差异计算身高降低值。我们使用线性回归模型来估计身高降低与骨密度测量值之间的关联。基线和再次调查之间的平均间隔为（8.0±0.8）年。33.0%的参与者身高降低≥1.0厘米，另有3.7%的参与者身高降低≥3.0厘米。在对潜在混杂因素进行调整后，身高降低与骨密度之间存在线性相关性（所有线性趋势P均<0.001）。身高每降低1.0厘米，宽带超声衰减（BUA）的β（95%CI）为 - 0.79（-0.95 - - 0.63），声速（SOS）为 - 2.74（-3.35 - - 2.13），硬度指数（SI）为 - 1.29（-1.54 - - 1.04）。与身高稳定的参与者相比，身高降低≥3.0厘米的参与者经多变量调整后的β（95%CI），BUA为 - 3.29（-4.08 - - 2.50），SOS为 - 10.70（-13.66 - - 7.73），SI为 - 5.16（-6.36 - - 3.96）。根据亚组分析，身高降低与骨密度测量值之间的关联在女性、年龄≥55岁以及身体活动较少的人群中似乎更为明显。骨密度随着身高降低的增加而降低。定期测量身高可能有助于骨质疏松症的早期诊断和预防。
