Chen F X, Zhu Z, Cui L, Yu H, Han R Q, Luo P F, Zhou J Y, Wu M
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Department of Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Jun 10;41(6):934-939. doi: 10.3760/cma.j.cn112338-20190920-00685.
To evaluate the associations between CYP24A1 genetic polymorphisms and related risks on breast cancer among postmenopausal women. We carried out a population-based case-control study to include 1 134 postmenopausal women (589 cases and 545 controls) from Wuxi, Jiangsu province and to explore the association between CYP24A1 polymorphisms and related risks on breast cancer. Seven CYP24A1 variants (rs2209314, rs2585428, rs2762941, rs3787555, rs4909959, rs912505 and rs927650) were genotyped by Sequenom MassARRAY platform. Logistic regression method was used to estimate the CYP24A1 genetic variants and susceptibility of breast cancer. Loci-loci interactions were evaluated by a generalized multifactor dimensionality reduction (GMDR) method. Result showed that rs2209314, rs2585428, rs2762941, rs3787555, rs4909959, rs912505 and rs927650 of CYP24A1 were not associated with breast cancer under the codominant, dominant, recessive or additive models. Among the population with <80 cm waist circumstance, rs2585428 was associated with the reduced risks on breast cancer (=0.64, 95: 0.42-0.96). Similar negative association was observed for rs3787555 (=0.58, 95: 0.38-0.87). The genotypes of rs2585428, rs3787555 and rs4909959 showed significant interactions with waist circumstance on the risk of breast cancer. Also, rs2209314, rs3787555 and rs912505 in CYP24A1 could alter the risk of breast cancer by way of loci-loci interaction. CYP24A1 variants rs2585428 and rs3787555 were associated with risks of susceptibility on breast cancer, among postmenopausal women.
为评估绝经后女性中CYP24A1基因多态性与乳腺癌相关风险之间的关联。我们开展了一项基于人群的病例对照研究，纳入了来自江苏省无锡市的1134名绝经后女性（589例病例和545例对照），以探索CYP24A1基因多态性与乳腺癌相关风险之间的关联。通过Sequenom MassARRAY平台对7个CYP24A1变体（rs2209314、rs2585428、rs2762941、rs3787555、rs4909959、rs912505和rs927650）进行基因分型。采用逻辑回归方法评估CYP24A1基因变体与乳腺癌易感性。通过广义多因素降维（GMDR）方法评估基因座-基因座相互作用。结果显示，在共显性、显性、隐性或加性模型下，CYP24A1的rs2209314、rs2585428、rs2762941、rs3787555、rs4909959、rs912505和rs927650与乳腺癌均无关联。在腰围<80 cm的人群中，rs2585428与乳腺癌风险降低相关（比值比=0.64，95%置信区间：0.42 - 0.96）。rs3787555也观察到类似的负相关（比值比=0.58，95%置信区间：0.38 - 0.87）。rs2585428、rs3787555和rs4909959的基因型在乳腺癌风险上与腰围存在显著相互作用。此外，CYP24A1中的rs2209314、rs3787555和rs912505可通过基因座-基因座相互作用改变乳腺癌风险。CYP24A1变体rs2585428和rs3787555与绝经后女性乳腺癌易感性风险相关。
