Department of Community Medicine and School of Public Health, Chandigarh, India
Department of Paediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Pediatr Endocrinol Diabetes Metab. 2020;26(2):79-83. doi: 10.5114/pedm.2020.95627.
There are limited data on the alterations of serum copper and zinc, which have been proposed to have associations among children with obesity.
A total of 173 children were enrolled and grouped into overweight/obese (n = 69) and non-obese (n = 104) according to CDC 2000 growth charts. Serum and whole blood zinc and copper concentrations were measured by validated ICP-MS method, and copper/zinc ratios were calculated and correlated to various anthropometric parameters.
Mean BMI in obese (24.78 ±3.93) was significantly higher as compared to non-obese (16.44 ±2.34; p < 0.0001, 95% CI: 15.9873-16.8998) children. Mean serum copper levels in obese children (1099.80 ±478.67 µg/l) were significantly lower than for non-obese children (2063.77 ±1006.81 µg/l; p = 0.0001, 95% CI: 1867.9755-2259.5755). Similarly, the mean serum zinc levels in obese children (851.53 ±406.33 µg/l) were also significantly lower as compared to non-obese children (1528.72 ±796.82 µg/l; p = 0.0001, 95% CI: 1373.76-1683.6879). Mean whole blood copper levels were significantly lower in obese (929.56 ±200.15 µg/l) as compared to non-obese (1393.22 ±861.92 µg/l; p = 0.0001, 95% CI: 1225.6023-1560.8481) children. Similarly, the mean whole blood zinc levels in obese (4384.11 ±881.87 µg/l) were also significantly lower as compared to non-obese (5380.14 ±2236.77 µg/l; p = 0.001, 95% CI: 4945.1491-5815.1416) children.
The serum and whole blood concentrations of zinc and copper were found to be significantly lower in children with exogenous obesity as compared to controls. Additional investigations are recommended to see the underlying aspect of these elements in the development of obesity along with their co-morbidities.
关于血清铜和锌的变化的数据有限，而这些变化据称与肥胖儿童有关。
共纳入 173 名儿童，并根据 CDC 2000 生长图表将其分为超重/肥胖（n=69）和非肥胖（n=104）。使用经过验证的 ICP-MS 方法测量血清和全血锌和铜浓度，并计算铜/锌比值，并与各种人体测量参数相关联。
肥胖儿童的平均 BMI（24.78±3.93）明显高于非肥胖儿童（16.44±2.34;p<0.0001，95%CI：15.9873-16.8998）。肥胖儿童的血清铜水平（1099.80±478.67µg/l）明显低于非肥胖儿童（2063.77±1006.81µg/l;p=0.0001，95%CI：1867.9755-2259.5755）。同样，肥胖儿童的血清锌水平（851.53±406.33µg/l）也明显低于非肥胖儿童（1528.72±796.82µg/l;p=0.0001，95%CI：1373.76-1683.6879）。肥胖儿童的全血铜水平（929.56±200.15µg/l）明显低于非肥胖儿童（1393.22±861.92µg/l;p=0.0001，95%CI：1225.6023-1560.8481）。同样，肥胖儿童的全血锌水平（4384.11±881.87µg/l）也明显低于非肥胖儿童（5380.14±2236.77µg/l;p=0.001，95%CI：4945.1491-5815.1416）。
与对照组相比，肥胖儿童的血清和全血锌和铜浓度明显降低。建议进一步研究这些元素在肥胖及其合并症发展中的潜在作用。
