Department of Neurology, Faculty of Medicine, Airlangga University, Surabaya Indonesia, Indonesia.
Department of Medical Biology and Biochemistry, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
Indian J Pharmacol. 2020 Mar-Apr;52(2):134-137. doi: 10.4103/ijp.IJP_655_18. Epub 2020 Jun 3.
Valproic acid (VA) is the antiepileptic, antimigraine and anti-mental disturbances agent. The use of VA is correlated to metabolic rearrangements including changes of lipoproteins; however, these effects still in debate. Herewith we analyze the effect of long-term VA treatment in the level of total cholesterol among adult. Sixty (30 case groups and 30 control groups) participants were asked for venous blood collection to examine the level of total cholesterol by enzymatic cholesterol oxidase phenol 4-aminoantipyrine peroxidase. The relationship of the long-term VA treatment and the level of total cholesterol was obtained from the analysis using the logistic regression analysis. Our analysis depicts that there is a relationship between the long-term VA treatment and the level of total cholesterol (P=0.024, odds ratio 0.272, 95% confidence interval 0.088-0.844). in conclusion, the long-term VA treatment reduces the level of total cholesterol in adult.
丙戊酸（VA）是一种抗癫痫、抗偏头痛和抗精神障碍的药物。VA 的使用与代谢重排有关，包括脂蛋白的变化；然而，这些影响仍存在争议。在此，我们分析了长期 VA 治疗对成年人总胆固醇水平的影响。我们要求 60 名（30 例病例组和 30 例对照组）参与者采集静脉血，通过酶法胆固醇氧化酶苯酚 4-氨基安替比林过氧化物酶检测总胆固醇水平。通过逻辑回归分析获得长期 VA 治疗与总胆固醇水平之间的关系。我们的分析表明，长期 VA 治疗与总胆固醇水平之间存在关系（P=0.024，优势比 0.272，95%置信区间 0.088-0.844）。总之，长期 VA 治疗可降低成年人的总胆固醇水平。
