School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
J Mater Chem B. 2020 Jul 28;8(28):6148-6158. doi: 10.1039/d0tb00982b. Epub 2020 Jun 22.
The addition of osteoimmunology drugs to bone repair materials is beneficial to bone regeneration by regulating the local immune microenvironment. Fingolimod (FTY720) has been reported to be an osteoimmunology drug that promotes osteogenesis. However, there is no ideal biomaterial for the sustained release of FTY720 in the bone defect areas. In the present work, FTY720 loaded mesoporous bioactive glass (FTY720@MBGs) was successfully prepared based on the mesoporous properties of MBGs and electrostatic attraction. FTY720 achieved a sustained release for 7 days. The in vitro study found that FTY720@MBGs could synergistically promote osteogenesis and inhibit osteoclastogenesis due to their ability to promote macrophages toward the M2 phenotype. The in vivo study confirmed that FTY720@MBGs could significantly improve bone regeneration. This study provides new strategies for designing smart cell-instructive biomaterials that can play a role in all bone healing processes from early inflammation to bone reconstruction.
骨免疫学药物的加入有利于通过调节局部免疫微环境来促进骨再生。芬戈莫德（FTY720）已被报道为一种促进成骨的骨免疫学药物。然而，在骨缺损区域中，还没有理想的生物材料可以用于 FTY720 的持续释放。在本工作中，基于 MBGs 的介孔特性和静电吸引力，成功制备了载 FTY720 的介孔生物活性玻璃（FTY720@MBGs）。FTY720 实现了 7 天的持续释放。体外研究发现，FTY720@MBGs 由于能够促进巨噬细胞向 M2 表型分化，从而协同促进成骨和抑制破骨细胞生成。体内研究证实，FTY720@MBGs 可显著改善骨再生。本研究为设计智能细胞指导型生物材料提供了新策略，这些材料可以在从早期炎症到骨重建的所有骨愈合过程中发挥作用。
