Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina; and.
Department of Biomedical Engineering, Duke University, Durham, North Carolina.
Retina. 2021 Apr 1;41(4):804-811. doi: 10.1097/IAE.0000000000002897.
Deformations of the retina such as staphylomas in myopia or scleral flattening in high intracranial pressure can be challenging to quantify with en face imaging. We describe an optical coherence tomography-based method for the generation of quantitative posterior eye topography maps in normal and pathologic eyes.
Using "whole eye" optical coherence tomography, we corrected for subjects' optical distortions to generate spatially accurate posterior eye optical coherence tomography volumes and created local curvature (KM, mm-1) topography maps for each consented subject. We imaged nine subjects, three normal, two with myopic degeneration, and four with papilledema including one that was imaged longitudinally.
Normal subjects mean temporal KM was 0.0923 mm-1, nasal KM was 0.0927 mm-1, and KM local variability was 0.0162 mm-1. In myopic degeneration, subjects KM local variability was higher at 0.0836 mm-1. In papilledema subjects nasal KM was flatter compared with temporal KM (0.0709 vs. 0.0885 mm-1). Mean intrasession KM repeatability for all subjects was 0.0036 mm-1.
We have developed an optical coherence tomography based method for quantitative posterior eye topography that offers the ability to analyze local curvature with micron scale resolution and offers the potential to help clinicians and researchers characterize subtle, local retinal deformations earlier in patients and follow their development over time.
在近视患者中的眼球后葡萄肿或高颅内压患者中的巩膜扁平变形等视网膜变形，使用共面成像技术进行定量评估具有一定挑战性。我们描述了一种基于光学相干断层扫描的方法，用于生成正常和病理眼的定量后眼部地形图。
使用“全眼”光学相干断层扫描，我们校正了受试者的光学扭曲，以生成空间准确的后眼部光学相干断层扫描体积，并为每位同意的受试者创建了局部曲率（KM，mm-1）地形图。我们对 9 名受试者进行了成像，包括 3 名正常受试者、2 名近视变性患者和 4 名视乳头水肿患者，其中 1 名患者进行了纵向成像。
正常受试者的颞侧 KM 平均值为 0.0923mm-1，鼻侧 KM 平均值为 0.0927mm-1，KM 局部变异性为 0.0162mm-1。在近视变性患者中，受试者的 KM 局部变异性更高，为 0.0836mm-1。在视乳头水肿患者中，鼻侧 KM 比颞侧 KM 更平坦（0.0709 与 0.0885mm-1）。所有受试者的日内 KM 重复性平均值为 0.0036mm-1。
我们开发了一种基于光学相干断层扫描的定量后眼部地形图分析方法，该方法具有以微米级分辨率分析局部曲率的能力，并有可能帮助临床医生和研究人员更早地识别患者细微的局部视网膜变形，并随时间跟踪其发展。
