Wang Shou-Feng, Wang Zeng-Mian, Song Wei-Dong, Tang Zhao-Chen, Chai Ying
First Ward of Orthopedics Department.
Third Ward of Neurology Department, First Affiliated Hospital of Jiamusi University, Jiamusi.
Medicine (Baltimore). 2020 Jun 19;99(25):e20484. doi: 10.1097/MD.0000000000020484.
This study will explore the efficacy and safety of intrathecal baclofen bolus (IBB) on neuropathic pain (NPP) in patients with spinal cord injury (SCI).
All potential literatures of IBB on NPP in patients with SCI will be searched from the following electronic databases from inauguration to the January 31, 2020: PUBMED, EMBASE, Cochrane Library, Web of Science, Chinese Scientific Journal Database Information, WANGFANG, and China National Knowledge Infrastructure. In addition, we will search other sources, such as dissertations and reference lists of included trials. There are no restrictions of language and publication status in searching all literature sources. The quality of each eligible trial will be assessed using Cochrane risk of bias tool, and publication bias will be checked using a funnel plot and Egger test. Statistical analysis will be conducted using RevMan 5.3 software.
This study will scrutinize the efficacy and safety of IBB on NPP in patients with SCI through pain intensity of NPP, spasticity, walking ability, health-related quality of life, duration of stay at hospital (days), incidence of adverse event, and mortality rate.
The findings of this study will present helpful evidence to judge whether IBB is effective on NPP in patients with SCI or not.
INPLASY202040192.
本研究将探讨鞘内注射巴氯芬推注（IBB）对脊髓损伤（SCI）患者神经性疼痛（NPP）的疗效和安全性。
从以下电子数据库建库至2020年1月31日，检索所有关于IBB治疗SCI患者NPP的潜在文献：PUBMED、EMBASE、Cochrane图书馆、科学网、中国科学期刊数据库信息、万方和中国知网。此外，我们还将检索其他来源，如学位论文和纳入试验的参考文献列表。在检索所有文献来源时，不受语言和出版状态的限制。使用Cochrane偏倚风险工具评估每个符合条件试验的质量，并使用漏斗图和Egger检验检查发表偏倚。使用RevMan 5.3软件进行统计分析。
本研究将通过NPP的疼痛强度、痉挛、行走能力、健康相关生活质量、住院天数、不良事件发生率和死亡率，仔细审查IBB对SCI患者NPP的疗效和安全性。
本研究结果将为判断IBB对SCI患者NPP是否有效提供有用的证据。
INPLASY202040192。
