Li Tong, Wang Yiran, Feng Chaoqun, Li Qianchun, Ran Qiang, Chen Botao, Yu Yang, Jiang Leiming, Fan Xiaohong
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, PR China.
Medicine (Baltimore). 2020 Dec 4;99(49):e23536. doi: 10.1097/MD.0000000000023536.
Hyperbaric oxygen (HBO) therapy can prevent further spinal cord injury (SCI) caused by spinal cord ischemia-reperfusion injury to the maximum extent, which has been reported increasingly in recent years. However its security and effectiveness still lack of high-quality medical evidence. In this study, we will perform a systematic review of previously published randomized controlled trials (RCTs) to evaluate the efficacy and safety of HBO therapy for SCI.
All potential RCTs on HBO therapy for SCI will be searched from the following electronic databases: PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, Wanfang database and Chinese Biomedical Literature Database. We will search all electronic databases from their initiation to the September 30, 2020 in spite of language and publication date. Two contributors will independently select studies from all searched literatures, extract data from included trials, and evaluate study quality for all eligible RCTs using Cochrane risk of bias tool, respectively. Any confusion will be resolved by consulting contributor and a consensus will be reached. We will utilize RevMan 5.3 software to pool the data and to conduct the data analysis.
The quality of the assessments will be assessed through Grading of Recommendations Assessment, Development, and Evaluation. Data will be disseminated through publications in peer-reviewed journals.
This study will provide evidence to evaluate the efficacy and safety of HBO therapy for SCI at evidence-based medicine level.
INPLASY 2020100084.
高压氧（HBO）疗法能最大程度预防脊髓缺血再灌注损伤所致的进一步脊髓损伤（SCI），近年来相关报道日益增多。然而，其安全性和有效性仍缺乏高质量医学证据。在本研究中，我们将对既往发表的随机对照试验（RCT）进行系统评价，以评估HBO疗法治疗SCI的疗效和安全性。
将从以下电子数据库检索所有关于HBO疗法治疗SCI的潜在RCT：PubMed、Embase、Cochrane图书馆、Web of Science、中国知网、中国科技期刊数据库、万方数据库和中国生物医学文献数据库。无论语言和发表日期，我们将检索所有电子数据库自创建至2020年9月30日的文献。两名研究人员将分别从所有检索到的文献中独立选择研究，从纳入试验中提取数据，并使用Cochrane偏倚风险工具评估所有符合条件的RCT的研究质量。任何分歧将通过咨询研究人员解决并达成共识。我们将使用RevMan 5.3软件汇总数据并进行数据分析。
将通过推荐分级评估、制定和评价来评估评估质量。数据将通过在同行评审期刊上发表进行传播。
本研究将为在循证医学层面评估HBO疗法治疗SCI的疗效和安全性提供证据。
INPLASY 2020100084。
