State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Jiangxi Province Key Laboratory of Modern Analytical Science, Nanchang University, Nanchang 330031, China.
Food Chem. 2020 Nov 30;331:127311. doi: 10.1016/j.foodchem.2020.127311. Epub 2020 Jun 12.
A magnetic hydrophilic molecularly imprinted material (MIM) with multiple stimuli-responses was prepared for efficient recognition of bisphenol A (BPA). MIM consisted of a magnetic core, an inner silica dioxide shell and an outer hydrophilic polymer shell, responsive for rapid magnetic separation, protection of the magnetic core and pH-/thermo-sensitivity to BPA, respectively. Controlled adsorption and release of BPA by pH/temperature regulation were realized through the reversible components of poly[N-isopropylacrylamide-co-2-(dimethylamino)ethyl methacrylate (NIPAM-DMAEMA)] (PND). The resultant MIM possessed superior affinity, selectivity and kinetics to BPA in aqueous solution. MIM was successfully applied to detect BPA in beverages via dispersive solid-phase extraction (d-SPE) coupled with high performance liquid chromatography (HPLC), exhibiting satisfactory recoveries of 80.70-108.18% with relative standard deviations (RSD) below 6.08%. The limit of detection of BPA was obtained as low as 3.75 nmol/L. The versatile MIM could be a promising alternative for extraction/removal of BPA in complicated samples by multiple-stimuli regulations.
一种具有多重刺激响应的磁性亲水分子印迹材料（MIM）被制备用于高效识别双酚 A（BPA）。MIM 由磁性核、内二氧化硅壳和外亲水聚合物壳组成，分别对快速磁分离、磁性核的保护以及对 BPA 的 pH/热响应具有响应性。通过聚[N-异丙基丙烯酰胺-co-2-（二甲氨基）乙基甲基丙烯酸酯（NIPAM-DMAEMA）]（PND）的可逆组件，实现了通过 pH/温度调节对 BPA 的控制吸附和释放。所得 MIM 在水溶液中对 BPA 具有优异的亲和力、选择性和动力学性能。通过分散固相萃取（d-SPE）与高效液相色谱（HPLC）联用，MIM 成功地应用于饮料中 BPA 的检测，回收率为 80.70-108.18%，相对标准偏差（RSD）低于 6.08%。BPA 的检测限低至 3.75 nmol/L。多功能 MIM 可以通过多重刺激调节，成为从复杂样品中提取/去除 BPA 的一种很有前途的替代方法。
