Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Basel, 4051 Basel, Switzerland.
Int J Mol Sci. 2020 Jun 18;21(12):4344. doi: 10.3390/ijms21124344.
Exosomes are nanovesicles part of a recently described intercellular communication system. Their properties seem promising as a biomarker in cancer research, where more sensitive monitoring and therapeutic applications are desperately needed. In the case of head and neck squamous cell carcinoma (HNSCC), overall survival often remains poor, although huge technological advancements in the treatment of this disease have been made. In the following review, diagnostic and therapeutic properties are highlighted and summarised. Impressive first results have been obtained but more research is needed to implement these innovative techniques into daily clinical routines.
外泌体是最近描述的细胞间通讯系统的纳米囊泡的一部分。它们作为癌症研究中的生物标志物具有很大的应用潜力，在癌症研究中迫切需要更敏感的监测和治疗应用。在头颈部鳞状细胞癌（HNSCC）的情况下，尽管在该疾病的治疗方面取得了巨大的技术进步，但总体生存率仍不理想。在下面的综述中，突出和总结了其诊断和治疗特性。已经取得了令人印象深刻的初步结果，但需要进一步的研究将这些创新技术应用于日常临床实践中。
