Li Ting, Li Juan, Wang Haitao, Zhao Jiayu, Yan Mingze, He Hongjiang, Yu Shan
Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
Department of Pathology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Front Mol Biosci. 2022 Jun 14;9:881794. doi: 10.3389/fmolb.2022.881794. eCollection 2022.
Head and neck squamous cell carcinoma (HNSCC), originating from the mucosal epithelial cells of the oral cavity, pharynx, and larynx, is a lethal malignancy of the head and neck. Patients with advanced and recurrent HNSCC have poor outcomes due to limited therapeutic options. Exosomes have active roles in the pathophysiology of tumors and are suggested as a potential therapeutic target of HNSCC. Exosomes in HNSCC have been intensively studied for disease activity, tumor staging, immunosuppression, and therapeutic monitoring. In this review, the biological mechanisms and the recent clinical application of exosomes are highlighted to reveal the potential of exosomes as biomarkers and therapeutic targets for HNSCC.
头颈部鳞状细胞癌（HNSCC）起源于口腔、咽和喉的黏膜上皮细胞，是一种致命的头颈部恶性肿瘤。晚期和复发性HNSCC患者由于治疗选择有限，预后较差。外泌体在肿瘤的病理生理学中发挥着积极作用，并被认为是HNSCC的潜在治疗靶点。HNSCC中的外泌体已被深入研究用于疾病活性、肿瘤分期、免疫抑制和治疗监测。在这篇综述中，外泌体的生物学机制和近期临床应用被重点强调，以揭示外泌体作为HNSCC生物标志物和治疗靶点的潜力。
