Gan Chen, Li Wen, Xu Jian, Pang Lulian, Tang Lingxue, Yu Sheng, Li Anlong, Ge Han, Huang Runze, Cheng Huaidong
Department of Oncology, The Second Affiliated Hospital of Anhui Medical University Hefei, Anhui, China.
Department of Oncology, Anhui Medical University Hefei, Anhui, China.
Am J Cancer Res. 2023 Aug 15;13(8):3275-3299. eCollection 2023.
Radiation therapy is one of the most commonly used treatments for head and neck cancers, but it often leads to radiation-induced brain injury. Patients with radiation-induced brain injury have a poorer quality of life, and no effective treatments are available. The pathogenesis of this condition is unknown. This review summarizes the molecular biological mechanism of radiation-induced brain injury and provides research directions for future studies. The molecular mechanisms of radiation-induced brain injury are diverse and complex. Radiation-induced chronic neuroinflammation, destruction of the blood-brain barrier, oxidative stress, neuronal damage, and physiopathological responses caused by specific exosome secretion lead to radiation-induced brain injury.
放射治疗是头颈癌最常用的治疗方法之一，但它常常导致放射性脑损伤。放射性脑损伤患者的生活质量较差，且目前尚无有效的治疗方法。这种疾病的发病机制尚不清楚。本综述总结了放射性脑损伤的分子生物学机制，并为未来的研究提供了方向。放射性脑损伤的分子机制多样且复杂。辐射诱导的慢性神经炎症、血脑屏障的破坏、氧化应激、神经元损伤以及特定外泌体分泌引起的生理病理反应导致了放射性脑损伤。
