Kolar Milan, Cermak Pavel, Hobzova Lenka, Bogdanova Katerina, Neradova Katerina, Mlynarcik Patrik, Bostik Pavel
Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University, and University Hospital, 779 00 Olomouc, Czech Republic.
Department of Microbiology, Thomayer Hospital, 140 59 Prague, Czech Republic.
Antibiotics (Basel). 2020 Jun 18;9(6):342. doi: 10.3390/antibiotics9060342.
Hospitalized patients with wounds face an increased risk of infection with multi-drug-resistant nosocomial bacteria. In this study, samples from almost 10,000 patients from big hospitals in Czech Republic with infected wounds were analyzed for the presence of bacterial pathogens. In 7693 patients (78.8%), bacterial etiological agents were identified. Members of the (37.1%) and (21.1%) were the most prevalent pathogens. showed methicillin resistance in 8.6%. Almost half of the isolates were ESBL-positive and 25.6% of the spp. isolates were AmpC-positive. The third most prevalent showed resistance to 19-32% of the antipseudomonal antibiotics tested. Based on the results, amoxicillin/clavulanic acid, ampicillin/sulbactam or piperacillin/tazobactam combined with gentamicin can be recommended for antibiotic treatment of infected wounds. Once the etiological agent is identified, the therapy should be adjusted according to the species and its resistance.
住院的伤口患者面临感染多重耐药医院细菌的风险增加。在本研究中，对来自捷克共和国大型医院近10000例有感染伤口患者的样本进行了细菌病原体检测。在7693例患者（78.8%）中鉴定出细菌病原体。（37.1%）和（21.1%）的成员是最常见的病原体。显示8.6%的耐甲氧西林。几乎一半的分离株为ESBL阳性，25.6%的 spp. 分离株为AmpC阳性。第三常见的对19%-32%的测试抗假单胞菌抗生素耐药。根据结果，阿莫西林/克拉维酸、氨苄西林/舒巴坦或哌拉西林/他唑巴坦联合庆大霉素可推荐用于感染伤口的抗生素治疗。一旦确定病原体，应根据菌种及其耐药性调整治疗方案。
