Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA.
Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Development. 2020 Jun 22;147(12):dev162263. doi: 10.1242/dev.162263.
The cochlea, a coiled structure located in the ventral region of the inner ear, acts as the primary structure for the perception of sound. Along the length of the cochlear spiral is the organ of Corti, a highly derived and rigorously patterned sensory epithelium that acts to convert auditory stimuli into neural impulses. The development of the organ of Corti requires a series of inductive events that specify unique cellular characteristics and axial identities along its three major axes. Here, we review recent studies of the cellular and molecular processes regulating several aspects of cochlear development, such as axial patterning, cochlear outgrowth and cellular differentiation. We highlight how the precise coordination of multiple signaling pathways is required for the successful formation of a complete organ of Corti.
耳蜗是位于内耳腹侧的一个螺旋结构，是感知声音的主要结构。沿着耳蜗螺旋的长度是柯蒂氏器，这是一种高度特化和严格模式化的感觉上皮，它将听觉刺激转化为神经冲动。柯蒂氏器的发育需要一系列诱导事件来指定其三个主要轴上独特的细胞特征和轴向身份。在这里，我们回顾了最近关于调节耳蜗发育几个方面的细胞和分子过程的研究，如轴向模式形成、耳蜗延伸和细胞分化。我们强调了多个信号通路的精确协调对于完整的柯蒂氏器的成功形成是如何必需的。
