de la Cour Cecilie Dovey, Sperling Cecilie Dyg, Belmonte Federica, Syrjänen Stina, Verdoodt Freija, Kjaer Susanne Krüger
Danish Cancer Society Research Center, Unit of Virus, Lifestyle and Genes, Copenhagen, Denmark.
Unit of Statistics and Pharmacoepidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark.
Head Neck. 2020 Oct;42(10):2975-2984. doi: 10.1002/hed.26330. Epub 2020 Jun 23.
The purpose of this systematic review and meta-analysis was to estimate the overall and type-specific prevalence of human papillomavirus (HPV) DNA in oral epithelial dysplasia and assess p16 overexpression in relation to HPV-status. A systematic literature search identified 31 eligible studies (832 cases) evaluating the presence of HPV DNA in oral epithelial dysplasia cases by PCR. Of these, six studies evaluated p16 overexpression in relation to HPV-status. The overall pooled prevalence of HPV DNA in oral epithelial dysplasia was 27.2% (95% CI: 17.6-38.1). We observed substantial interstudy heterogeneity, which could not be explained by differences in continent, tissue type, or severity of epithelial dysplasia. HPV16 was the predominant genotype detected. Moreover, 62.2% of HPV positive and 17.8% of HPV negative oral epithelial dysplasia samples stained intensively positive for p16 . This meta-analysis found that 27% of oral epithelial dysplasia harbor HPV DNA. Whether this represents a transient infection or has a carcinogenic role is unknown.
本系统评价和荟萃分析的目的是估计口腔上皮发育异常中人类乳头瘤病毒（HPV）DNA的总体及特定类型患病率，并评估与HPV状态相关的p16过表达情况。一项系统文献检索确定了31项符合条件的研究（832例病例），这些研究通过聚合酶链反应（PCR）评估口腔上皮发育异常病例中HPV DNA的存在情况。其中，六项研究评估了与HPV状态相关的p16过表达情况。口腔上皮发育异常中HPV DNA的总体合并患病率为27.2%（95%置信区间：17.6 - 38.1）。我们观察到研究间存在显著异质性，这种异质性无法用大陆、组织类型或上皮发育异常严重程度的差异来解释。HPV16是检测到的主要基因型。此外，62.2%的HPV阳性和17.8%的HPV阴性口腔上皮发育异常样本p16染色呈强阳性。该荟萃分析发现，27%的口腔上皮发育异常含有HPV DNA。这是代表短暂感染还是具有致癌作用尚不清楚。
