Atlanta Oral Pathology, Emory at Decatur Hospital, Emory University School of Medicine, Decatur, GA, USA.
Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka.
Head Neck Pathol. 2022 Mar;16(1):54-62. doi: 10.1007/s12105-021-01402-9. Epub 2022 Mar 21.
The fifth chapter of the upcoming fifth edition of the 2022 World Health Organization Classification of Tumours of the Head and Neck titled Tumours of the oral cavity and mobile tongue, has had some modifications from the 2017 fourth edition. A new section "Non-neoplastic Lesions", introduces two new entries: necrotizing sialometaplasia and melanoacanthoma. The combined Oral potentially malignant disorders and Oral epithelial dysplasia section in the 2015 WHO has now been separated and submucous fibrosis and HPV-associated dysplasia are also discussed in separate sections. Carcinoma cuniculatum and verrucous carcinoma are described in dedicated sections, reflecting that the oral cavity is the most common location in the head and neck for both these entities which have distinct clinical and histologic features from conventional squamous cell carcinoma. This review summarizes the changes in Chapter 5 with special reference to new additions, deletions, and sections that reflect current clinical, histological, and molecular advances.
即将出版的第五版《2022 年世界卫生组织头颈部肿瘤分类》第五章题为“口腔和活动舌肿瘤”，与 2017 年第四版相比有一些修改。新增了一个新的“非肿瘤性病变”小节，引入了两个新条目：坏死性唾液腺化生和黑素棘皮瘤。2015 年世卫组织的“口腔潜在恶性疾病和口腔上皮异型增生”小节现在已分开，黏膜下纤维化和 HPV 相关异型增生也在单独的小节中讨论。“兔唇样癌”和“疣状癌”在专门的小节中进行了描述，这反映出口腔是这两种实体在头颈部最常见的部位，它们与常规的鳞状细胞癌在临床和组织学特征上有明显的区别。本文综述了第五章的变化，特别提到了新增、删除和反映当前临床、组织学和分子进展的小节。
