Department of Biochemistry, Faculty of Health and Life Sciences, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom.
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
Front Immunol. 2020 May 28;11:1221. doi: 10.3389/fimmu.2020.01221. eCollection 2020.
Lactoferrin is a nutrient classically found in mammalian milk. It binds iron and is transferred via a variety of receptors into and between cells, serum, bile, and cerebrospinal fluid. It has important immunological properties, and is both antibacterial and antiviral. In particular, there is evidence that it can bind to at least some of the receptors used by coronaviruses and thereby block their entry. Of importance are Heparan Sulfate Proteoglycans (HSPGs) and the host receptor angiotensin-converting enzyme 2 (ACE2), as based on other activities lactoferrin might prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from attaching to the host cells. Lactoferrin (and more specifically enteric-coated LF because of increased bioavailability) may consequently be of preventive and therapeutic value during the present COVID-19 pandemic.
乳铁蛋白是一种经典存在于哺乳动物乳中的营养物质。它可以结合铁，并通过多种受体在细胞内外、血清、胆汁和脑脊液之间进行转移。它具有重要的免疫学特性，具有抗菌和抗病毒作用。特别是有证据表明，它可以与冠状病毒至少部分使用的受体结合，从而阻止它们的进入。硫酸乙酰肝素蛋白聚糖 (HSPGs) 和宿主受体血管紧张素转换酶 2 (ACE2) 很重要，因为基于其他活性，乳铁蛋白可能会阻止严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 附着在宿主细胞上。乳铁蛋白（更具体地说是肠溶包衣 LF，因为生物利用度增加）因此可能在当前的 COVID-19 大流行期间具有预防和治疗价值。
