Stone R A, Kuwayama Y
Arch Ophthalmol. 1985 Aug;103(8):1207-11. doi: 10.1001/archopht.1985.01050080119031.
Using immunohistochemical methods, substance P is localized to nerves of the human eye. Immunoreactive nerve fibers occur in the cornea, about limbal blood vessels, and within the trabecular meshwork. Substance P-like immunoreactive nerve fibers surround uveal blood vessels, especially in the choroid and ciliary body. Immunoreactive nerves are seen in ciliary processes. The ciliary muscle is innervated, as are the iris dilator and sphincter muscles. Apposition of immunoreactive nerves to uveal melanocytes is apparent. The distribution of substance P-like immunoreactive nerves in the human eye parallels that found in other mammals. While substance P probably has important neurotransmitter or neuromodulator roles in the eye, further physiologic studies are required to define its ocular function.
运用免疫组化方法，发现P物质定位于人眼的神经中。免疫反应性神经纤维存在于角膜、角膜缘血管周围以及小梁网内。P物质样免疫反应性神经纤维围绕葡萄膜血管，尤其是在脉络膜和睫状体中。在睫状突可见免疫反应性神经。睫状肌受神经支配，虹膜开大肌和瞳孔括约肌也如此。免疫反应性神经与葡萄膜黑素细胞相邻明显。人眼中P物质样免疫反应性神经的分布与在其他哺乳动物中发现的相似。虽然P物质可能在眼中具有重要的神经递质或神经调节作用，但需要进一步的生理学研究来确定其眼部功能。
