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High TLR4 expression predicts a poor prognosis after esophagectomy for advanced thoracic esophageal squamous cell carcinoma.TLR4 高表达预示着晚期胸段食管鳞癌患者行食管癌根治术后预后不良。
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2
KCNJ15 Expression and Malignant Behavior of Esophageal Squamous Cell Carcinoma.KCNJ15 的表达与食管鳞癌的恶性行为。
Ann Surg Oncol. 2020 Jul;27(7):2559-2568. doi: 10.1245/s10434-019-08189-8. Epub 2020 Feb 12.
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Analysis of the National Cancer Database Esophageal Squamous Cell Carcinoma in the United States.美国国家癌症数据库食管鳞癌分析。
Ann Thorac Surg. 2019 Nov;108(5):1535-1542. doi: 10.1016/j.athoracsur.2019.05.053. Epub 2019 Jul 11.
4
CBX2 Regulates Proliferation and Apoptosis via the Phosphorylation of YAP in Hepatocellular Carcinoma.CBX2通过YAP磷酸化调控肝癌细胞的增殖和凋亡
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Addition of Docetaxel to Oral Fluoropyrimidine Improves Efficacy in Patients With Stage III Gastric Cancer: Interim Analysis of JACCRO GC-07, a Randomized Controlled Trial.多西他赛联合口服氟嘧啶可提高 III 期胃癌患者的疗效：JACCRO GC-07 随机对照试验的中期分析。
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染色盒蛋白 2 表达预测食管鳞癌根治性切除术后的预后。

Chromobox 2 Expression Predicts Prognosis After Curative Resection of Oesophageal Squamous Cell Carcinoma.

机构信息

Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Department of Maxillofacial Surgery, School of Dentistry, Aichi-gakuin University Graduate School of Medicine, Nagoya, Japan.

出版信息

Cancer Genomics Proteomics. 2020 Jul-Aug;17(4):391-400. doi: 10.21873/cgp.20198.

DOI:10.21873/cgp.20198
PMID:32576584
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7367605/
Abstract

BACKGROUND/AIM: To investigate the function of chromobox 2 (CBX2) in oesophageal squamous cell carcinoma (OSCC).

MATERIALS AND METHODS

We used real-time quantitative reverse transcription PCR (qRT-PCR) and immunohistochemistry to determine CBX2 expression levels in 13 human OSCC cell lines and clinical specimens of two independent cohorts of patients with OSCC.

RESULTS

PCR array analysis revealed that CBX2 was co-ordinately expressed with WNT5B in OSCC cell lines. RT-qPCR analysis of clinical samples revealed a high tumour-specific CBX2 expression compared with normal oesophageal tissues. High CBX2 expression was significantly associated with shorter disease-specific survival, hematogenous recurrence, and overall recurrence. Analysis of tissue microarrays of one cohort revealed that patients with higher CBX2 levels tended to have a shorter disease-specific survival.

CONCLUSION

CBX2 overexpression in OSCC tissues may serve as a novel biomarker for predicting survival and hematogenous recurrence.

摘要

背景/目的：研究染色质盒蛋白 2（CBX2）在食管鳞癌（OSCC）中的作用。

材料与方法

我们采用实时定量逆转录聚合酶链反应（qRT-PCR）和免疫组织化学技术，检测了 13 个人食管鳞癌细胞系和两个独立的 OSCC 患者队列的临床标本中 CBX2 的表达水平。

结果

PCR 阵列分析显示，CBX2 在食管鳞癌细胞系中与 WNT5B 协同表达。临床样本的 RT-qPCR 分析显示，与正常食管组织相比，肿瘤组织中 CBX2 的表达水平较高。高 CBX2 表达与疾病特异性生存率、血行复发和总复发显著相关。对一个队列的组织微阵列分析显示，CBX2 水平较高的患者疾病特异性生存率较低。

结论

OSCC 组织中 CBX2 的过度表达可能成为预测生存和血行复发的新型生物标志物。