College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Antiviral Res. 2020 Oct;182:104827. doi: 10.1016/j.antiviral.2020.104827. Epub 2020 Jun 21.
Feline calicivirus (FCV) is a highly contagious pathogen that causes acute upper respiratory infections and oral disease in cats, thus seriously endangering feline health. Recently, there have been outbreaks of particularly virulent variant strains of FCV, which can cause both acute symptoms and fatal systemic disease. The discovery of effective antiviral agents to treat FCV infection is, therefore, gradually assuming increased importance. In this study, we showed that both nitazoxanide and mizoribine had antiviral activity in F81 cells infected with different strains of FCV and also demonstrated a synergistic effect between the two drugs. Experiments in cats challenged with FCV showed that nitazoxanide significantly reduced the clinical symptoms of FCV infection, reduced viral load in the trachea and lungs, and reduced viral shedding. Our results showed that nitazoxanide and mizoribine could potentially be used as therapeutic agents to treat FCV infection.
猫杯状病毒（FCV）是一种高度传染性病原体，可导致猫急性上呼吸道感染和口腔疾病，严重危害猫的健康。最近，FCV 的特别毒力变异株爆发，可引起急性症状和致命的全身疾病。因此，发现有效治疗 FCV 感染的抗病毒药物逐渐变得越来越重要。在这项研究中，我们表明硝唑尼特和咪康唑在感染不同 FCV 株的 F81 细胞中均具有抗病毒活性，并证明了这两种药物之间具有协同作用。用 FCV 攻毒的猫实验表明，硝唑尼特可显著减轻 FCV 感染的临床症状，降低气管和肺部的病毒载量，并减少病毒脱落。我们的结果表明，硝唑尼特和咪康唑可能可作为治疗 FCV 感染的治疗剂。
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