State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Lanzhou, Gansu, China.
College of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Arch Virol. 2021 Sep;166(9):2443-2450. doi: 10.1007/s00705-021-05107-w. Epub 2021 Jun 25.
Cats infected with feline calicivirus (FCV) often display oral ulcers and inflammation of the upper respiratory tract, which can lead to death in severe cases. Antiviral therapy is one of the most effective ways to control FCV infection. Natural compounds in Chinese herbal medicines and medicinal plants provide abundant resources for research on antiviral drugs. In this study, we found that icariin (ICA), formononetin (FMN) and caffeic acid phenethyl ester (CPAE) show low cytotoxicity towards F81 cells, that the three natural compounds have apparent antiviral effects on FCV in vitro, and that they can inhibit different FCV strains. Then, we found that ICA and FMN mainly function in the early stage of FCV infection, while CAPE can function in both the early and late stages of FCV infection. Finally, we found that ICA has an antagonistic effect on FMN and CAPE in FCV infection, and FMN has a synergistic effect with CAPE against FCV infection. Our results showed that ICA, FMN and CAPE may be potential drug candidates for FCV-induced diseases.
感染猫杯状病毒（FCV）的猫通常会出现口腔溃疡和上呼吸道炎症，在严重的情况下可能导致死亡。抗病毒治疗是控制 FCV 感染最有效的方法之一。中草药和药用植物中的天然化合物为抗病毒药物的研究提供了丰富的资源。在这项研究中，我们发现淫羊藿苷（ICA）、芒柄花素（FMN）和咖啡酸苯乙酯（CPAE）对 F81 细胞的细胞毒性低，这三种天然化合物对 FCV 具有明显的体外抗病毒作用，并且可以抑制不同的 FCV 株。然后，我们发现 ICA 和 FMN 主要在 FCV 感染的早期起作用，而 CAPE 可以在 FCV 感染的早期和晚期起作用。最后，我们发现 ICA 在 FCV 感染中对 FMN 和 CAPE 具有拮抗作用，而 FMN 与 CAPE 对 FCV 感染具有协同作用。我们的结果表明，ICA、FMN 和 CAPE 可能是 FCV 诱导疾病的潜在药物候选物。
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