Centre of Experimental and Clinical Regenerative Medicine, University of Veterinary Medicine and Pharmacy in Kosice, Slovak Republic.
Physiol Res. 2022 Apr 30;71(2):199-208. doi: 10.33549/physiolres.934802. Epub 2022 Mar 28.
The adult human brain represents only 2% of the body's total weight, however it is one of the most metabolically active organs in the mammalian body. Its high metabolic activity necessitates an efficacious waste clearance system. Besides the blood, there are two fluids closely linked to the brain and spinal cord drainage system: interstitial fluid (ISF) and cerebrospinal fluid (CSF). The aim of this review is to summarize the latest research clarifying the channels of metabolite removal by fluids from brain tissue, subarachnoid space (SAS) and brain dura (BD). Special attention is focused on lymphatic vascular structures in the brain dura, their localizations within the meninges, morphological properties and topographic anatomy. The review ends with an account of the consequences of brain lymphatic drainage failure. Knowledge of the physiological state of the clearance system is crucial in order to understand the changes related to impaired brain drainage.
成人的大脑仅占人体总重量的 2%，但它却是哺乳动物体内新陈代谢最活跃的器官之一。其高代谢活性需要一个有效的废物清除系统。除了血液，还有两种与脑和脊髓引流系统密切相关的液体：细胞间液（ISF）和脑脊液（CSF）。本综述的目的是总结最近的研究成果，阐明液体从脑组织、蛛网膜下腔（SAS）和脑硬脑膜（BD）中清除代谢物的途径。特别关注脑硬脑膜中的淋巴血管结构，它们在脑膜中的位置、形态特征和局部解剖结构。综述最后还讨论了脑淋巴引流失败的后果。了解清除系统的生理状态对于理解与脑引流受损相关的变化至关重要。
