Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Obes Res Clin Pract. 2020 Jul-Aug;14(4):321-325. doi: 10.1016/j.orcp.2020.05.007. Epub 2020 Jun 21.
Endocannabinoids especially anadamide (AEA) and 2‑arachidonoylglycerol (2-AG) together with appetite modulators have recently been of great importance in body weight regulation and obesity incidence. The present study was carried out to investigate AEA and 2-AG levels and their association with leptin, insulin, orexin - A, and anthropometric indices in obese women.
The demographic and anthropometric data of 180 overweight/ obese women with mean age 34.2±8.27 years old, and mean BMI 32.54±3.73kg/m were evaluated. The plasma levels of anadamide and 2‑arachidonoylglycerol levels and also serum levels of leptin, insulin and orexin- A concentrations were measured. Pearson and spearmen correlation tests along with hieratical regression test were used to assess the association of endocannabinoids levels with anthropometric indices and appetite modulators.
Significant correlations were revealed between AEA and 2-AG with leptin, BMI, waist circumference (WC) and body fat percent (BF%) (P<0.001). 2-AG levels correlated positively with mean insulin levels (P<0.001). Neither AEA nor 2-AG correlated significantly with serum orexin - A levels. Leptin, insulin, BMI, WC, and BF% were significant independent predictors of AEA and 2-AG in the hierarchical regression model (P<.001) and explained 65% and 68% of variance in AEA and 2-AG respectively (P<0.001).
The findings showed that levels of AEA and 2-AG were associated with BMI, WC, BF%, and leptin and insulin levels. Also, BMI, WC, BF%, leptin and, insulin levels can have predictive value for determining AEA and 2-AG.
内源性大麻素，特别是花生四烯酸乙醇酰胺（AEA）和 2-花生四烯酸甘油（2-AG），以及食欲调节剂，最近在体重调节和肥胖发生率方面非常重要。本研究旨在调查肥胖女性中 AEA 和 2-AG 水平及其与瘦素、胰岛素、食欲素-A 和人体测量指数的关系。
评估了 180 名超重/肥胖女性的人口统计学和人体测量数据，平均年龄 34.2±8.27 岁，平均 BMI 32.54±3.73kg/m。测量了花生四烯酸乙醇酰胺和 2-花生四烯酸甘油的血浆水平，以及血清瘦素、胰岛素和食欲素-A 浓度。使用 Pearson 和 Spearmen 相关检验以及层次回归检验评估内源性大麻素水平与人体测量指数和食欲调节剂的关系。
AEA 和 2-AG 与瘦素、BMI、腰围（WC）和体脂肪百分比（BF%）呈显著相关（P<0.001）。2-AG 水平与平均胰岛素水平呈正相关（P<0.001）。AEA 和 2-AG 与血清食欲素-A 水平均无显著相关性。在层次回归模型中，瘦素、胰岛素、BMI、WC 和 BF% 是 AEA 和 2-AG 的显著独立预测因子（P<.001），分别解释了 AEA 和 2-AG 变异的 65%和 68%（P<0.001）。
研究结果表明，AEA 和 2-AG 水平与 BMI、WC、BF%、瘦素和胰岛素水平相关。此外，BMI、WC、BF%、瘦素和胰岛素水平可用于预测 AEA 和 2-AG。
