Yagin Neda Lotfi, Hajjarzadeh Samaneh, Aliasgharzadeh Soghra, Aliasgari Fereshteh, Mahdavi Reza
Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Lipids Health Dis. 2020 Jul 6;19(1):161. doi: 10.1186/s12944-020-01341-4.
Higher levels of anandamide (AEA) and 2-arachidonoylglycerol (2-AG), the main arachidonic acid-derived endocannabinoids, are frequently reported in overweight and obese individuals. Recently, endocannabinoids have become a research interest in obesity area regarding their role in food intake. The relationship between dietary patterns and endocannabinoids is poorly understood; therefore, this study evaluated the association of the dietary patterns with AEA and 2-AG levels in overweight and obese women.
In this cross sectional study, 183 overweight and obese females from Tabriz, Iran who aged between 19 and 50 years old and with mean BMI = 32.44 ± 3.79 kg/m were interviewed. The AEA and 2-AG levels were measured, and the dietary patterns were assessed using food frequency questionnaire. To extract the dietary patterns, factor analysis was applied. The association between AEA and 2-AG levels and dietary patterns was analyzed by linear regression.
Three major dietary patterns including "Western", "healthy", and "traditional" were extracted. After adjusting for age, physical activity, BMI, waist circumference, and fat mass, higher levels of AEA and 2-AG were observed in participants who were in the highest quintile of the Western pattern (P < 0.05). Also, in both unadjusted and adjusted models, significantly lower levels of AEA and 2-AG were detected in the women of the highest quintile of the healthy pattern (P < 0.01). Moreover, there was no significant association between "traditional" pattern and AEA and 2- AG levels in both unadjusted and adjusted models (P > 0.05).
In regard with the lower levels of endocannabinoids in healthy dietary pattern, adherence to healthy pattern might have promising results in regulating endocannabinoids levels.
超重和肥胖个体中，花生四烯酸衍生的主要内源性大麻素——花生四烯乙醇胺（AEA）和2-花生四烯酸甘油酯（2-AG）的水平通常较高。最近，内源性大麻素因其在食物摄入中的作用，已成为肥胖领域的研究热点。饮食模式与内源性大麻素之间的关系尚不清楚；因此，本研究评估了超重和肥胖女性的饮食模式与AEA和2-AG水平之间的关联。
在这项横断面研究中，对来自伊朗大不里士的183名年龄在19至50岁之间、平均BMI为32.44±3.79kg/m的超重和肥胖女性进行了访谈。测量了AEA和2-AG水平，并使用食物频率问卷评估了饮食模式。采用因子分析提取饮食模式。通过线性回归分析AEA和2-AG水平与饮食模式之间的关联。
提取了三种主要饮食模式，即“西方”、“健康”和“传统”模式。在调整年龄、身体活动、BMI、腰围和脂肪量后，处于西方模式最高五分位数的参与者中观察到较高水平的AEA和2-AG（P<0.05）。此外，在未调整和调整模型中，处于健康模式最高五分位数的女性中检测到的AEA和2-AG水平均显著较低（P<0.01）。此外，在未调整和调整模型中，“传统”模式与AEA和2-AG水平之间均无显著关联（P>0.05）。
鉴于健康饮食模式中内源性大麻素水平较低，坚持健康模式可能在调节内源性大麻素水平方面产生良好效果。
