Amirinejad Roya, Rezaei Mina, Shirvani-Farsani Zeinab
Genetics Department, Breast Cancer Research Center, Motamed Center Institute, ACECR, Tehran, Iran.
Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.C, Tehran, Iran.
Cell Biosci. 2020 Jun 22;10:82. doi: 10.1186/s13578-020-00445-9. eCollection 2020.
Long intergenic noncoding RNA p21 was mapped on the human chromosome 6p21.2. Accordingly, it was firstly described by promoting the p53-dependent apoptosis in the mouse. Also, it is a new lncRNA playing some vital roles in the cell cycle, apoptosis, cell proliferation, tumorigenesis, invasion, metastasis, and angiogenesis. In this regard, it was shown that, - regulates these biological processes involved in carcinogenesis through various signaling pathways including Notch signaling, JAK2/STAT3, and AKT/mTOR pathways. Another mechanism by that - can affect these processes is a cross-talk with different miRNAs. In vitro and in vivo studies revealed dysregulation of - in various human cancers. In addition, emerging evidence demonstrated that, - can be considered as a potential prognostic and therapeutic biomarker in cancers. Also, - enhances the response to radiotherapy for colorectal cancer. However, the molecular mechanisms of - in carcinogenesis have not been fully elucidated so far. So, this review summarizes the function of - as a tumor suppressor factor in different biological processes implicated in cancers.
长链基因间非编码RNA p21定位于人类6号染色体p21.2区域。因此，它最初是在小鼠中通过促进p53依赖的细胞凋亡而被描述的。此外，它是一种新的长链非编码RNA，在细胞周期、细胞凋亡、细胞增殖、肿瘤发生、侵袭、转移和血管生成中发挥着重要作用。在这方面，研究表明，它通过包括Notch信号通路、JAK2/STAT3和AKT/mTOR通路在内的各种信号通路调节参与致癌作用的这些生物学过程。它影响这些过程的另一种机制是与不同的微小RNA相互作用。体外和体内研究揭示了它在各种人类癌症中的表达失调。此外，新出现的证据表明，它可被视为癌症潜在的预后和治疗生物标志物。而且，它增强了结直肠癌对放疗的反应。然而，到目前为止，它在致癌作用中的分子机制尚未完全阐明。因此，本综述总结了它作为肿瘤抑制因子在癌症相关不同生物学过程中的功能。
