Hiramatsu M, Kashimata M, Sato A, Murayama M, Minami N
Department of Dental Pharmacology, Josai Dental University, Saitama, Japan.
Experientia. 1988 Jan 15;44(1):23-5. doi: 10.1007/BF01960230.
The influence of age on 125I-epidermal growth factor (EGF) binding to rat brain plasma membranes was investigated. The specific binding of EGF to membranes decreased gradually with age in both male and female rats. There was no significant difference in the specific binding between males and females. Scatchard analysis of the binding data showed that the decrease in EGF binding with age was due to a decrease in the number of EGF receptors.
研究了年龄对125I-表皮生长因子（EGF）与大鼠脑细胞膜结合的影响。在雄性和雌性大鼠中，EGF与膜的特异性结合均随年龄增长而逐渐降低。雄性和雌性之间的特异性结合没有显著差异。对结合数据进行Scatchard分析表明，EGF结合随年龄增长而降低是由于EGF受体数量减少所致。
