Bhowmick Biswajit, Han Qian
Key Laboratory of Tropical Biological Resources of Ministry of Education, Hainan University, Haikou, China.
Laboratory of Tropical Veterinary Medicine and Vector Biology, School of Life and Pharmaceutical Sciences, Hainan University, Haikou, China.
Front Vet Sci. 2020 Jun 9;7:319. doi: 10.3389/fvets.2020.00319. eCollection 2020.
Ticks are obligate blood-feeding ectoparasites that transmit a wide variety of pathogens to animals and humans in many parts of the world. Currently, tick control methods primarily rely on the application of chemical acaricides, which results in the development of resistance among tick populations and environmental contamination. Therefore, an alternative tick control method, such as vaccines have been shown to be a feasible strategy that offers a sustainable, safe, effective, and environment-friendly solution. Nevertheless, novel control methods are hindered by a lack of understanding of tick biology, tick-pathogen-host interface, and identification of effective antigens in the development of vaccines. This review highlights the current knowledge and data on some of the tick-protective antigens that have been identified for the formulation of anti-tick vaccines along with the effects of these vaccines on the control of tick-borne diseases.
蜱是专性吸血的体外寄生虫，在世界许多地区将多种病原体传播给动物和人类。目前，蜱虫控制方法主要依赖于化学杀螨剂的应用，这导致蜱虫种群产生抗药性并造成环境污染。因此，一种替代的蜱虫控制方法，如疫苗，已被证明是一种可行的策略，提供了一种可持续、安全、有效且环保的解决方案。然而，由于对蜱虫生物学、蜱虫-病原体-宿主界面缺乏了解以及在疫苗开发中难以识别有效抗原，新型控制方法受到了阻碍。本综述重点介绍了一些已确定用于制备抗蜱疫苗的蜱虫保护性抗原的现有知识和数据，以及这些疫苗对蜱传疾病控制的影响。
