通过针对类似于Ia的非SD（Ag-B）位点的抗体对大鼠肾同种异体移植进行被动增强，并证明与主要组织相容性复合体（MHC）存在连锁关系。
Passive enhancement of rat renal allografts by antibodies to a non-SD (Ag-B) locus analogous to Ia and demonstration of linkage to the MHC.
作者信息
Catto G R, Carpenter C B, Strom T B, Williams R M
出版信息
Transplant Proc. 1977 Mar;9(1):957-60.
The rat MHC contains a distinct locus for Ia-like antigens. The alleles of this locus are not always associated with like alleles of the MLR and Ag-B (SD) loci in inbred strains. This is demonstrated by the Fischer strain, which is MLR and tag-B (SD) 1 (H-11) but shares an Ia specificity with BN (Ag-B3, H-1n). The biologic significance of anti-Ia is distinctive, having in vivo graft-enhancing capability, even when it is cross-reacting (i.e., Lew anti-Fi enhances BN). In contrast, anti-AG-B (SD) does not enhance in the rat model.
大鼠主要组织相容性复合体（MHC）包含一个与Ia类抗原相关的独特基因座。在近交系中，该基因座的等位基因并不总是与混合淋巴细胞反应（MLR）和Ag-B（SD）基因座的相似等位基因相关联。这在费希尔（Fischer）品系中得到了证明，该品系是MLR和tag-B（SD）1（H-11），但与BN（Ag-B3，H-1n）共享一种Ia特异性。抗Ia的生物学意义独特，即使是交叉反应性的（即Lew抗-Fi增强BN），在体内也具有移植物增强能力。相比之下，抗AG-B（SD）在大鼠模型中不会增强。
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