Montoya-Pedrón A, Ocaña-Montoya C M, Bolaño-Díaz G A
Hospital General " Dr. Juan Bruno Zayas Alfonso", Santiago de Cuba, Cuba.
Hospital General "Dr. Juan Bruno Zayas Alfonso", Santiago de Cuba, Cuba.
Rev Neurol. 2020 Jul 1;71(1):11-18. doi: 10.33588/rn.7101.2019341.
The value of the P300 cognitive event-related potential in the diagnosis of Alzheimer subtype neurocognitive disorders is still incipient. Recent studies suggest that combining it with neuropsychological tests by cognitive domains would allow an objective and early characterisation of the cognitive impairment in its initial stages.
To characterise the electrophysiological patterns in the P300 potential that obtain a discriminatory value for the diagnosis and classification of the neurocognitive disorders with a possible Alzheimer-type aetiology.
This study examines 39 patients classified, according to the DSM-5, with possible Alzheimer-type minor and major neurocognitive disorders, aged between 50 and 85 years, and 53 control subjects with normal cognitive functions. The P300 potential is registered in the auditory mode, oddball paradigm and centroparietal recording.
P300 latency is significantly prolonged in subjects with neurocognitive disorder; there are significant differences in the mean values and confidence intervals between healthy controls and patients. No significant differences are obtained in P300 latency between groups with minor and major neurocognitive disorder. The mean amplitude value decreases in neurocognitive disorder, and the P300 amplitude logarithm of the control groups and those with minor and major neurocognitive disorder reaches significantly different mean values and confidence intervals.
The parameters quantified in the P300 potential can be used as complementary biomarkers to classify the presence and level of cognitive dysfunction with a possible Alzheimer-type aetiology.
P300认知事件相关电位在阿尔茨海默病亚型神经认知障碍诊断中的价值仍处于初始阶段。最近的研究表明，将其与按认知领域进行的神经心理学测试相结合，能够在认知障碍的初始阶段对其进行客观且早期的特征描述。
描述P300电位中的电生理模式，这些模式可为具有可能的阿尔茨海默病型病因的神经认知障碍的诊断和分类提供鉴别价值。
本研究检查了39例根据《精神疾病诊断与统计手册》第5版分类为可能的轻度和重度阿尔茨海默病型神经认知障碍的患者，年龄在50至85岁之间，以及53名认知功能正常的对照受试者。P300电位通过听觉模式、oddball范式和中央顶叶记录进行记录。
神经认知障碍患者的P300潜伏期显著延长；健康对照组与患者之间的平均值和置信区间存在显著差异。轻度和重度神经认知障碍组之间的P300潜伏期未获得显著差异。神经认知障碍患者的平均波幅降低，对照组以及轻度和重度神经认知障碍组的P300波幅对数达到显著不同的平均值和置信区间。
P300电位中量化的参数可作为补充生物标志物，用于对具有可能的阿尔茨海默病型病因的认知功能障碍的存在和程度进行分类。
