Department of Otorhinolaryngology-Head and Neck Surgery, Peking University People's Hospital, Beijing, 100044, China.
Sci Rep. 2024 Jun 19;14(1):14117. doi: 10.1038/s41598-024-65014-3.
This study aims to investigate auditory hypersensitivity and cortical function in migraine patients using the Hyperacusis Questionnaire and the Event-Related Potential (ERP) technique. The study analyzes alterations in the latency and amplitude of the event-related potentials MMN and P300 components. The findings contribute to a better understanding of the physiological relationship between migraine and auditory hypersensitivity. Seventeen migraine patients were admitted to the outpatient clinic of the Department of Otorhinolaryngology-Head and Neck Surgery at Peking University People's Hospital from June 2023 to September 2023. Nineteen matched healthy subjects were also selected. All participants underwent the pure tone audiometry and the auditory brainstem response test to determine hearing thresholds, the Hyperacusis Questionnaire, the Tinnitus Handicap Inventory, and an ERP examination. The Oddball classical paradigm was used as the stimulation task, and electroencephalography signals were recorded synchronously. The scores of the Hyperacusis Questionnaire, latency and amplitude of MMN and P300 component were compared between the migraine group and the control group, and their correlation was analyzed. The latency of MMN at the Fz and Cz sites in migraine patients was significantly shorter than that in the control group (P < 0.05), and the amplitudes were significantly higher than those in the control group (P < 0.05). The variances in latency and amplitude of P300 at Cz and Pz sites in migraine patients were not statistically significant when compared with the control group. (P > 0.05). The Hyperacusis Questionnaire was negatively correlated with MMN latency, with a correlation coefficient of - 0.374 (P = 0.025), and positively correlated with MMN amplitude, with a correlation coefficient of 0.378 (P = 0.023). There was no significant similarity between the Hyperacusis Questionnaire and P300 latency and amplitude (P > 0.05). Overall, auditory hypersensitivity was enhanced in individuals with migraines compared to healthy individuals, leading to faster information processing, while there may be less impairment in cognitive function.
本研究旨在通过使用听觉超敏问卷和事件相关电位（ERP）技术来研究偏头痛患者的听觉过敏和皮质功能。该研究分析了事件相关电位 MMN 和 P300 成分潜伏期和振幅的变化。研究结果有助于更好地理解偏头痛和听觉过敏之间的生理关系。
2023 年 6 月至 2023 年 9 月，17 名偏头痛患者被收入北京大学人民医院耳鼻喉科门诊，同时选择了 19 名匹配的健康受试者。所有参与者均接受了纯音听阈测试和听觉脑干反应测试，以确定听力阈值、听觉超敏问卷、耳鸣残疾量表和 ERP 检查。Oddball 经典范式被用作刺激任务，同时同步记录脑电图信号。比较偏头痛组和对照组之间听觉超敏问卷的评分、MMN 和 P300 成分的潜伏期和振幅，并分析它们之间的相关性。偏头痛患者 Fz 和 Cz 部位 MMN 的潜伏期明显短于对照组（P < 0.05），振幅明显高于对照组（P < 0.05）。偏头痛患者 Cz 和 Pz 部位 P300 潜伏期和振幅的方差与对照组相比无统计学意义（P > 0.05）。听觉超敏问卷与 MMN 潜伏期呈负相关，相关系数为-0.374（P = 0.025），与 MMN 振幅呈正相关，相关系数为 0.378（P = 0.023）。听觉超敏问卷与 P300 潜伏期和振幅之间没有显著相似性（P > 0.05）。
总之，与健康个体相比，偏头痛患者的听觉过敏增强，导致信息处理更快，而认知功能可能受损较小。
