标准化治疗和缩短抑郁病程可减轻青少年抑郁症患者的认知障碍。
Standardized Treatment and Shortened Depression Course can Reduce Cognitive Impairment in Adolescents With Depression.
作者信息
Cao Penghui, Tan Junjie, Liao Xuezhen, Wang Jinwei, Chen Lihuan, Fang Ziyan, Pan Nannan
机构信息
Institute of Neuropsychiatry, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Department of Nephrology and Immunohematology, Qingyuan Maternal and Child Health Hospital of Guangdong Province, Guangdong, China.
出版信息
J Korean Acad Child Adolesc Psychiatry. 2024 Jan 1;35(1):90-97. doi: 10.5765/jkacap.230052.
OBJECTIVES
This study aimed to explore the influence of depression severity, disease course, treatment status, and other factors on cognitive function in adolescents with depressive disorders.
METHODS
Participants who met the inclusion criteria were enrolled in the study. Sociodemographic data of each participant were recorded, including age, sex, and family history of mental disorders. Zung's Self-Rating Depression Scale was used to assess depression status in adolescents. Moreover, P300 and mismatch negativity (MMN) were used to objectively evaluate the participants' cognitive function.
RESULTS
Only 26.8% of the adolescents with depression received standard antidepressant treatment. The latencies of N2 (267.80±23.34 ms), P3 (357.71±32.09 ms), and MMN (212.10±15.61 ms) in the adolescent depression group were longer than those in the healthy control group (p<0.01). Further analysis revealed that the latency of MMN was extended with increased levels of depression in adolescents. The MMN latency was short in participants with depression receiving standardized treatment. Furthermore, the latency of MMN was positively correlated with the severity and duration of depression (correlation coefficients were 0.465 and 0.479, respectively) (p<0.01).
CONCLUSION
Receiving standardized treatment and shortening the course of depression can reduce cognitive impairment in adolescents with depression.
目的
本研究旨在探讨抑郁严重程度、病程、治疗状态及其他因素对青少年抑郁症患者认知功能的影响。
方法
符合纳入标准的参与者被纳入本研究。记录每位参与者的社会人口统计学数据，包括年龄、性别和精神障碍家族史。采用zung氏自评抑郁量表评估青少年的抑郁状态。此外，使用P300和失配负波（MMN）客观评估参与者的认知功能。
结果
仅有26.8%的青少年抑郁症患者接受了标准抗抑郁治疗。青少年抑郁症组的N2（267.80±23.34毫秒）、P3（357.71±32.09毫秒）和MMN（212.10±15.61毫秒）潜伏期长于健康对照组（p<0.01）。进一步分析显示，青少年抑郁水平升高时MMN潜伏期延长。接受标准化治疗的抑郁症参与者MMN潜伏期较短。此外，MMN潜伏期与抑郁严重程度和病程呈正相关（相关系数分别为0.465和0.479）（p<0.01）。
结论
接受标准化治疗并缩短抑郁病程可减轻青少年抑郁症患者的认知损害。
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