AbdEl-Azim Mohamed H M, Aziz Maged A, Mouneir Samar M, El-Farargy Ahmed F, Shehab Wesam S
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt.
Arch Pharm (Weinheim). 2020 Sep;353(9):e2000084. doi: 10.1002/ardp.202000084. Epub 2020 Jun 25.
A versatile, efficient, clean, and facile method was used for the synthesis of pyrano[2,3-d]pyrimidine derivatives by the one-pot three-component condensation reaction of thiobarbituric acid and malononitrile with p-chlorobenzaldehyde, using Fe O or ZnO or Mn O as nanostructure catalysts. The catalyst could be easily recovered using an external magnet and reused for six cycles with almost a consistent activity. A series of polyheterocyclic compounds containing five and/or six rings fused with each other was designed. The anti-inflammatory activities for some of the newly synthesized compounds were evaluated. All the synthesized compounds were characterized on the basis of their elemental analyses and spectral data.
采用一种通用、高效、清洁且简便的方法，通过硫代巴比妥酸、丙二腈与对氯苯甲醛的一锅三组分缩合反应来合成吡喃并[2,3 - d]嘧啶衍生物，使用Fe₃O₄或ZnO或MnO₂作为纳米结构催化剂。该催化剂可通过外部磁铁轻松回收，并能重复使用六个循环，且活性几乎保持一致。设计了一系列由五个和/或六个相互稠合的环组成的多杂环化合物。评估了一些新合成化合物的抗炎活性。所有合成的化合物均通过元素分析和光谱数据进行了表征。
