Sun Byung Joo, Park Jae Hyeong, Lee Minyeong, Choi Jin Oh, Lee Ju Hee, Shin Mi Seung, Kim Mi Jeong, Jung Hae Ok, Park Jeong Rang, Sohn Il Suk, Kim Hyungseop, Kim Hyung Kwan, Cho Goo Yeong, Park Jin Sun, Shim Chi Young, Shin Sung Hee, Kim Kye Hun, Kim Woo Shik, Park Seung Woo
Division of Cardiology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.
Cardiovascular Center, Chungnam National University Hospital, Daejeon, Korea.
J Cardiovasc Imaging. 2020 Jul;28(3):186-198. doi: 10.4250/jcvi.2020.0043.
Left atrial (LA) strain is a novel parameter of LA function. However, its reference value has not been established, and the determining factors for LA strain remain elusive. We aimed to present LA strain with reservoir, conduit, and contractile components and associated parameters in a large-sized group of healthy individuals.
The present study was from a prospective multicenter registry in South Korea. Subjects who had no history of cardiovascular disease with adequate images were eligible for inclusion. LA reservoir, conduit, and contractile strains (LAS, LAS and LAS, respectively) were measured. Left ventricular global longitudinal strain (LV GLS) and early and late diastolic strain rates (DSR and DSR, respectively) were also evaluated.
Among a total of 324 subjects (mean age: 49 ± 16 years, 167 females), the mean LAS, LAS, and LAS values were 35.9% ± 10.6%, 21.9% ± 9.3%, and 13.9% ± 3.6%, respectively. Mean LV GLS was -20.4% ± 2.2%, and mean DSR and DSR were 1.6 ± 0.4 s and 0.8 ± 0.3 s, respectively. With aging, LAS and LAS showed significant decreases. Factors showing independent associations with LAS were age (B = -0.425, p < 0.001), DSR (B = 4.706, p = 0.001), and LV GLS (B = -1.081, p < 0.001). Age (B = -0.319, p < 0.001), DSR (B = 4.140, p = 0.002), DSR (B = -3.409, p = 0.018), and LV GLS (B = -0.783, p < 0.001) showed associations with LAS. With LAS, only DSR showed a correlation (R = 0.277, p < 0.001).
We presented LA strain in a large-sized group of healthy subjects. Age is a significant determinant of LA function. Associations of LA strain with diastolic strain rates and LV GLS reflect cardiac mechanics.
左心房（LA）应变是评估LA功能的一个新参数。然而，其参考值尚未确定，LA应变的决定因素也仍不明确。我们旨在展示一大群健康个体的LA储备、管道和收缩成分应变以及相关参数。
本研究来自韩国一项前瞻性多中心注册研究。无心血管疾病史且图像质量合格的受试者符合纳入标准。测量LA储备、管道和收缩应变（分别为LAS、LAS和LAS）。还评估了左心室整体纵向应变（LV GLS）以及舒张早期和晚期应变率（分别为DSR和DSR）。
在总共324名受试者（平均年龄：49±16岁，167名女性）中，LAS、LAS和LAS的平均值分别为35.9%±10.6%、21.9%±9.3%和13.9%±3.6%。LV GLS的平均值为-20.4%±2.2%，DSR和DSR的平均值分别为1.6±0.4秒和0.8±0.3秒。随着年龄增长，LAS和LAS显著降低。与LAS显示独立关联的因素有年龄（B=-0.425，p<0.001）、DSR（B=4.706，p=0.001）和LV GLS（B=-1.081，p<0.001）。年龄（B=-0.319，p<0.001）、DSR（B=4.140，p=0.002）、DSR（B=-3.409，p=0.018）和LV GLS（B=-0.783，p<0.001）与LAS有关联。对于LAS，只有DSR显示出相关性（R=0.277，p<0.001）。
我们展示了一大群健康受试者的LA应变。年龄是LA功能的一个重要决定因素。LA应变与舒张应变率和LV GLS的关联反映了心脏力学。
