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Double-edged sword of ALDH2 mutations: one polymorphism can both benefit and harm the cardiovascular system.

作者信息

Bartoli-Leonard Francesca, Saddic Louis, Aikawa Elena

机构信息

Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Department of Anaesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

出版信息

Eur Heart J. 2020 Jul 7;41(26):2453-2455. doi: 10.1093/eurheartj/ehaa444.

DOI:10.1093/eurheartj/ehaa444
PMID:32585692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7340353/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/692d/7340353/719523e00638/eurheartj_41_26_2453_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/692d/7340353/719523e00638/eurheartj_41_26_2453_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/692d/7340353/719523e00638/eurheartj_41_26_2453_f1.jpg

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本文引用的文献

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Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype.通过醛脱氢酶2介导的血管平滑肌细胞表型转换预防主动脉夹层和动脉瘤
Eur Heart J. 2020 Jul 7;41(26):2442-2453. doi: 10.1093/eurheartj/ehaa352.
2
miR-31-5p Is a Potential Circulating Biomarker and Therapeutic Target for Oral Cancer.miR-31-5p是口腔癌潜在的循环生物标志物和治疗靶点。
Mol Ther Nucleic Acids. 2019 Jun 7;16:471-480. doi: 10.1016/j.omtn.2019.03.012. Epub 2019 Apr 11.
3
NF-κB-responsive miRNA-31-5p elicits endothelial dysfunction associated with preeclampsia via down-regulation of endothelial nitric-oxide synthase.
乙醛脱氢酶2通过破坏脓毒症休克中“线粒体-核苷酸结合寡聚化结构域样受体蛋白3炎性小体”信号通路来减轻心肌细胞焦亡。
Front Pharmacol. 2023 Mar 13;14:1125866. doi: 10.3389/fphar.2023.1125866. eCollection 2023.
4
The role of aldehyde dehydrogenase 2 in cardiovascular disease.乙醛脱氢酶 2 在心血管疾病中的作用。
Nat Rev Cardiol. 2023 Jul;20(7):495-509. doi: 10.1038/s41569-023-00839-5. Epub 2023 Feb 13.
5
Macrophage ALDH2 (Aldehyde Dehydrogenase 2) Stabilizing Rac2 Is Required for Efferocytosis Internalization and Reduction of Atherosclerosis Development.巨噬细胞 ALDH2（醛脱氢酶 2）稳定 Rac2 对于胞饮作用内化和减少动脉粥样硬化发展是必需的。
Arterioscler Thromb Vasc Biol. 2022 Jun;42(6):700-716. doi: 10.1161/ATVBAHA.121.317204. Epub 2022 Mar 31.
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Aldehyde Dehydrogenase 2 as a Therapeutic Target in Oxidative Stress-Related Diseases: Post-Translational Modifications Deserve More Attention.乙醛脱氢酶 2 作为氧化应激相关疾病的治疗靶点：翻译后修饰值得更多关注。
Int J Mol Sci. 2022 Feb 28;23(5):2682. doi: 10.3390/ijms23052682.
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The ALDH2 gene rs671 polymorphism is not associated with essential hypertension.ALDH2 基因 rs671 多态性与原发性高血压无关。
Clin Exp Hypertens. 2017;39(8):691-695. doi: 10.1080/10641963.2017.1299749. Epub 2017 Jun 14.
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Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis.乙醛脱氢酶2基因rs671多态性与原发性高血压之间的正相关关系：一项病例对照研究与荟萃分析
PLoS One. 2017 May 4;12(5):e0177023. doi: 10.1371/journal.pone.0177023. eCollection 2017.
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Aldehyde Dehydrogenase-2 Roles in Ischemic Cardiovascular Disease.乙醛脱氢酶-2 在缺血性心血管疾病中的作用。
Curr Drug Targets. 2017;18(15):1817-1823. doi: 10.2174/1389450117666160912174417.
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