ALDH2 基因 rs671 多态性与原发性高血压无关。
The ALDH2 gene rs671 polymorphism is not associated with essential hypertension.
机构信息
a Center of Molecular Medicine, Ruijin Hospital , Shanghai Jiao-tong University School of Medicine , Shanghai , P.R. China.
b Institute of Biomedical Sciences and Emergency Department , Minhang Hospital, Fudan University , Shanghai , P.R. China.
出版信息
Clin Exp Hypertens. 2017;39(8):691-695. doi: 10.1080/10641963.2017.1299749. Epub 2017 Jun 14.
Essential hypertension (EH) is a worldwide problem. Acetaldehyde dehydrogenase 2 (ALDH2) gene has been suggested to be correlated with EH. However, the results are inconsistent. This study aimed to investigate the associations of ALDH2 rs671 polymorphism with EH in a Chinese Han population in Shanghai. Genotype of ALDH2 rs671 was analyzed in 1923 EH patients and 1115 control subjects. We found no association between ALDH2 rs671 and EH risk or EH-related quantitative blood chemistry values. Furthermore, a meta-analysis was performed and the summary results from 11220 patients and 8339 control subjects were consistent with our findings. These results indicated that rs671 of ALDH2 may not associate with the risk of EH.
原发性高血压（EH）是一个全球性的问题。乙醛脱氢酶 2（ALDH2）基因被认为与 EH 相关。然而，结果并不一致。本研究旨在探讨中国上海汉族人群中 ALDH2 rs671 多态性与 EH 的相关性。对 1923 例 EH 患者和 1115 例对照的 ALDH2 rs671 基因型进行了分析。我们发现 ALDH2 rs671 与 EH 风险或 EH 相关的定量血液化学值之间没有关联。此外，还进行了一项荟萃分析，汇总了来自 11220 例患者和 8339 例对照的结果，与我们的发现一致。这些结果表明，ALDH2 的 rs671 可能与 EH 的发病风险无关。
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