Wu Yinyin, Ni Juntao, Cai Xiao, Lian Fuzhi, Ma Haiyan, Xu Liangwen, Yang Lei
School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
PLoS One. 2017 May 4;12(5):e0177023. doi: 10.1371/journal.pone.0177023. eCollection 2017.
Several studies have been conducted to examine the association between aldehyde dehydrogenase 2 family (ALDH2) rs671 polymorphism and essential hypertension (EH). However, the results remain inconsistent. This study aimed to clarify the association between ALDH2 rs671 polymorphism and EH susceptibility.
One thousand and ninety-four cases and 1236 controls who were ethnic Han Chinese were collected for this population-based case-control study. A meta-analysis was performed to calculate the pooled odds ratio and 95% confidence interval, using allele contrast, dominant, recessive, and co-dominant models using fixed or random-effect models.
Significant differences were observed between EH cases and controls at the level of both genotype (χ2 = 6.656, P<0.05) and alleles (χ2 = 6.314, P<0.05). An additional meta-analysis using 4204 cases and 5435 controls established that rs671 was significantly associated with EH (P<0.00001).
The results of our case-control study and meta-analysis showed that there is a significant association between ALDH2 rs671 polymorphism and EH susceptibility. In addition, the results of the breakdown analysis by gender suggest a male-specific association between the ALDH2 rs671 polymorphism and EH.
已经开展了多项研究来探讨乙醛脱氢酶2家族（ALDH2）rs671多态性与原发性高血压（EH）之间的关联。然而，结果仍不一致。本研究旨在阐明ALDH2 rs671多态性与EH易感性之间的关联。
本基于人群的病例对照研究收集了1094例汉族病例和1236例汉族对照。采用固定效应模型或随机效应模型，通过等位基因对比、显性、隐性和共显性模型进行荟萃分析，以计算合并比值比和95%置信区间。
在基因型水平（χ2 = 6.656，P<0.05）和等位基因水平（χ2 = 6.314，P<0.05），EH病例与对照之间均观察到显著差异。使用4204例病例和5435例对照进行的另一项荟萃分析表明rs671与EH显著相关（P<0.00001）。
我们的病例对照研究和荟萃分析结果表明，ALDH2 rs671多态性与EH易感性之间存在显著关联。此外，按性别进行的分组分析结果表明，ALDH2 rs671多态性与EH之间存在男性特异性关联。
