Laboratory of Immunotherapy and Bone Marrow Transplantation, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Int J Mol Sci. 2020 Jun 23;21(12):4448. doi: 10.3390/ijms21124448.
The plant contains numerous components, including cannabinoids and other active molecules. The phyto-cannabinoid activity is mediated by the endocannabinoid system. Cannabinoids affect the nervous system and play significant roles in the regulation of the immune system. While is not yet registered as a drug, the potential of cannabinoid-based medicines for the treatment of various conditions has led many countries to authorize their clinical use. However, the data from basic and medical research dedicated to medical is currently limited. A variety of pathological conditions involve dysregulation of the immune system. For example, in cancer, immune surveillance and cancer immuno-editing result in immune tolerance. On the other hand, in autoimmune diseases increased immune activity causes tissue damage. Immuno-modulating therapies can regulate the immune system and therefore the immune-regulatory properties of cannabinoids, suggest their use in the therapy of immune related disorders. In this contemporary review, we discuss the roles of the endocannabinoid system in immunity and explore the emerging data about the effects of cannabinoids on the immune response in different pathologies. In addition, we discuss the complexities of using cannabinoid-based treatments in each of these conditions.
该植物含有多种成分，包括大麻素和其他活性分子。植物大麻素的活性由内源性大麻素系统介导。大麻素影响神经系统，并在免疫系统的调节中发挥重要作用。虽然大麻素尚未被注册为药物，但基于大麻素的药物治疗各种疾病的潜力已促使许多国家授权其临床使用。然而，目前专门用于医学大麻的基础和医学研究的数据有限。多种病理状况涉及免疫系统的失调。例如，在癌症中，免疫监视和癌症免疫编辑导致免疫耐受。另一方面，在自身免疫性疾病中，免疫活性增加导致组织损伤。免疫调节疗法可以调节免疫系统，因此大麻素的免疫调节特性表明它们可用于治疗与免疫相关的疾病。在这篇当代综述中，我们讨论了内源性大麻素系统在免疫中的作用，并探讨了关于大麻素对不同病理中免疫反应影响的新兴数据。此外，我们还讨论了在这些情况下使用基于大麻素的治疗方法的复杂性。
