Graduate School of Agriculture, Forestry and Fisheries, Kagoshima University, Kagoshima 890-0065, Japan.
Department of Food Science & Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan.
Nutrients. 2020 Jun 23;12(6):1872. doi: 10.3390/nu12061872.
Vascular disease poses a major public health problem worldwide. Trigonelline isolated from cv. Sakurajima Daikon (Sakurajima radish) induces nitric oxide production from vascular endothelial cells and enhances vascular function. Here, we investigated the characteristics of trigonelline and its effects on endothelial function after consumption of Sakurajima radish by humans. Our results show that Sakurajima radish contains approximately 60 times more trigonelline than other radishes and squashes. Additionally, no significant differences were observed between varieties of Sakurajima radish, suggesting that any type of Sakurajima radish can be ingested for trigonelline supplementation. The effects of cooking and processing Sakurajima radish were also evaluated, as were the effects of freezing, and changes in osmotic pressure and pH. A first-in-human trial using Sakurajima radish showed that ingestion of 170 g/day of Sakurajima radish for ten days increased blood trigonelline concentrations and significantly improved flow-mediated dilation, which is a measure of vascular endothelial function. Overall, our findings suggest that the trigonelline contained in Sakurajima radish may contribute to improved human vascular endothelial function. Hence, Sakurajima radish may enhance vascular endothelial function as a functional food.
血管疾病是全球主要的公共卫生问题。从 cv. Sakurajima Daikon（樱岛萝卜）中分离出的六氢吡啶能诱导血管内皮细胞产生一氧化氮，并增强血管功能。在这里，我们研究了樱岛萝卜中六氢吡啶的特性及其对人体摄入樱岛萝卜后内皮功能的影响。我们的结果表明，樱岛萝卜中六氢吡啶的含量比其他萝卜和南瓜大约高 60 倍。此外，樱岛萝卜的品种之间没有明显差异，这表明任何类型的樱岛萝卜都可以摄入以补充六氢吡啶。我们还评估了烹饪和加工樱岛萝卜的效果，以及冷冻、渗透压和 pH 值变化的影响。一项使用樱岛萝卜的人体首次试验表明，连续十天每天摄入 170 克樱岛萝卜可增加血液中六氢吡啶的浓度，并显著改善血流介导的扩张，这是衡量血管内皮功能的一个指标。总的来说，我们的研究结果表明，樱岛萝卜中含有的六氢吡啶可能有助于改善人类的血管内皮功能。因此，樱岛萝卜作为一种功能性食品可能增强血管内皮功能。
