Eto Masumi, Yamazawa Toshiko, Kurahara Lin-Hai, Yamamura Aya, Kajiya Katsuko, Watanabe Masaru
Faculty of Veterinary Medicine, Okayama University of Science, Ehime 794-8555, Japan.
Core Research Facilities and Center for SI Medical Research, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
J Smooth Muscle Res. 2025;61:59-64. doi: 10.1540/jsmr.61.59.
Smooth muscle research is at the forefront of translational science, bridging the gap between basic molecular discoveries and clinical applications. The symposium "Muscle and Pathology/Health: Frontiers of Translational Research" at the 66th Annual Meeting of Japan Society of Smooth Muscle Research showcased recent advances in this field. The presentations highlighted diverse topics, including molecular targeting in malignant hyperthermia, the therapeutic potential of probiotics in inflammatory bowel disease, sex differences in pulmonary hypertension and the impact of dietary components on vascular health. These studies underscore the importance of precision therapies, personalized medicine and functional foods in understanding and managing diseases. As technological innovations continue to drive research, the symposium provided insight into future directions, such as developing targeted molecular therapies, leveraging probiotics for systemic effects, expanding sex-based studies, and industrializing outcomes of basic science. The findings presented offer promising avenues for new treatment strategies that could revolutionize smooth muscle-related healthcare, emphasizing the potential for improved patient outcomes through translational research.
平滑肌研究处于转化科学的前沿,弥合了基础分子发现与临床应用之间的差距。日本平滑肌研究学会第66届年会上的“肌肉与病理学/健康:转化研究前沿”研讨会展示了该领域的最新进展。报告突出了各种主题,包括恶性高热中的分子靶向、益生菌在炎症性肠病中的治疗潜力、肺动脉高压中的性别差异以及饮食成分对血管健康的影响。这些研究强调了精准疗法、个性化医疗和功能性食品在理解和管理疾病方面的重要性。随着技术创新不断推动研究发展,该研讨会提供了对未来方向的见解,例如开发靶向分子疗法、利用益生菌产生全身效应、扩大基于性别的研究以及将基础科学成果产业化。所展示的研究结果为新的治疗策略提供了有前景的途径,这些策略可能会彻底改变与平滑肌相关的医疗保健,强调了通过转化研究改善患者预后的潜力。