Hyun Nam Gyu, Hyun Kwangho, Oh Saecheol, Lee Kyungmin
Department of Physics, Jeju National University, Jeju 63243, Korea.
Jeju Eastern Health Center, Jeju 63357, Korea.
Korean J Physiol Pharmacol. 2020 Jul 1;24(4):349-362. doi: 10.4196/kjpp.2020.24.4.349.
Temperature affects the firing pattern and electrical activity of neurons in animals, eliciting diverse responses depending on neuronal cell type. However, the mechanisms underlying such diverse responses are not well understood. In the present study, we performed in vitro recording of abdominal ganglia cells of , and analyzed their burst firing patterns. We identified atypical bursting patterns dependent on temperature that were totally different from classical bursting patterns observed in R15 neurons of . We classified these abnormal bursting patterns into type 1 and type 2; type 1 abnormal single bursts are composed of two kinds of spikes with a long interspike interval (ISI) followed by short ISI regular firing, while type 2 abnormal single bursts are composed of complex multiplets. To investigate the mechanism underlying the temperature dependence of abnormal bursting, we employed simulations using a modified Plant model and determined that the temperature dependence of type 2 abnormal bursting is related to temperaturedependent scaling factors and activation or inactivation of potassium or sodium channels.
温度会影响动物神经元的放电模式和电活动，根据神经元细胞类型引发不同的反应。然而，这种多样反应背后的机制尚未得到充分理解。在本研究中，我们对[动物名称]的腹神经节细胞进行了体外记录，并分析了它们的爆发式放电模式。我们识别出了依赖于温度的非典型爆发模式，这些模式与在[动物名称]的R15神经元中观察到的经典爆发模式完全不同。我们将这些异常爆发模式分为1型和2型；1型异常单峰爆发由两种具有长峰间间隔（ISI）的尖峰组成，随后是短ISI的规则放电，而2型异常单峰爆发由复杂的多重峰组成。为了研究异常爆发对温度依赖性的机制，我们使用修改后的Plant模型进行模拟，并确定2型异常爆发的温度依赖性与温度依赖性缩放因子以及钾或钠通道的激活或失活有关。
