Perfetto L, Pastrello C, Del-Toro N, Duesbury M, Iannuccelli M, Kotlyar M, Licata L, Meldal B, Panneerselvam K, Panni S, Rahimzadeh N, Ricard-Blum S, Salwinski L, Shrivastava A, Cesareni G, Pellegrini M, Orchard S, Jurisica I, Hermjakob H H, Porras P
European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.
Krembil Research Institute, Data Science Discovery Centre for Chronic Diseases, University Health Network, 5KD-407, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada.
bioRxiv. 2020 Jun 16:2020.06.16.153817. doi: 10.1101/2020.06.16.153817.
The current Coronavirus Disease 2019 (COVID-19) pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has spurred a wave of research of nearly unprecedented scale. Among the different strategies that are being used to understand the disease and develop effective treatments, the study of physical molecular interactions enables studying fine-grained resolution of the mechanisms behind the virus biology and the human organism response. Here we present a curated dataset of physical molecular interactions, manually extracted by IMEx Consortium curators focused on proteins from SARS-CoV-2, SARS-CoV-1 and other members of the family. Currently, the dataset comprises over 2,200 binarized interactions extracted from 86 publications. The dataset can be accessed in the standard formats recommended by the Proteomics Standards Initiative (HUPO-PSI) at the IntAct database website ( www.ebi.ac.uk/intact ), and will be continuously updated as research on COVID-19 progresses.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019年冠状病毒病（COVID-19）大流行引发了一场规模几乎史无前例的研究热潮。在用于了解该疾病并开发有效治疗方法的不同策略中，对物理分子相互作用的研究有助于对病毒生物学背后的机制以及人体生物反应进行细粒度解析。在此，我们展示了一个经过整理的物理分子相互作用数据集，该数据集由国际分子相互作用数据库联盟（IMEx Consortium）的管理员手动提取，重点关注来自SARS-CoV-2、SARS-CoV-1及该病毒家族其他成员的蛋白质。目前，该数据集包含从86篇出版物中提取的2200多个二元相互作用。该数据集可在IntAct数据库网站（www.ebi.ac.uk/intact）以蛋白质组学标准倡议（HUPO-PSI）推荐的标准格式获取，并将随着对COVID-19研究的进展不断更新。
